2-Hydroxy-5-iodo-3-methoxybenzaldehyde

Base Information

• Chemical Name: 2-Hydroxy-5-iodo-3-methoxybenzaldehyde
• CAS No.: 7359-14-0
• Molecular Formula: C8H7IO3
• Molecular Weight: 278.046
• Hs Code.: 2913000090
• DSSTox Substance ID: DTXSID10427264
• Nikkaji Number: J2.572.738J
• Wikidata: Q82239959
• Mol file: 7359-14-0.mol

Synonyms:2-Hydroxy-5-iodo-3-methoxybenzaldehyde;7359-14-0;5-IODO-O-VANILLIN;YSZC595;SCHEMBL1527077;DTXSID10427264;KVQIQUILJIOMHJ-UHFFFAOYSA-N;MFCD00016594;AKOS024387402;2-Hydroxy-3-methoxy-5-iodobenzaldehyde;5-BENZYLOXY-2-NITROPHENYLPYRUVICACID;CS-0132092;FT-0636454

Chemical Property of 2-Hydroxy-5-iodo-3-methoxybenzaldehyde

Chemical Property:

• Vapor Pressure: 0.000113mmHg at 25°C
• Melting Point: 127-130°C
• Refractive Index: 1.671
• Boiling Point: 326.5°C at 760 mmHg
• Flash Point: 151.3°C
• PSA: 46.53000
• Density: 1.909g/cm³
• LogP: 1.81790
• XLogP3: 2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 277.94399
• Heavy Atom Count: 12
• Complexity: 162

Purity/Quality:

99.0%Min ^*data from raw suppliers

2-Hydroxy-5-iodo-3-methoxybenzaldehyde ^*data from reagent suppliers

Safty Information:

• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC(=CC(=C1O)C=O)I
• Uses: is used in preparation of α,β-unsaturated amide compounds having anti-cancer activity.

Technology Process of 2-Hydroxy-5-iodo-3-methoxybenzaldehyde

There total 1 articles about 2-Hydroxy-5-iodo-3-methoxybenzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

3-methoxy-2-hydroxybenzaldehyde (148-53-8) → 2-hydroxy-5-iodo-3-methoxybenzaldehyde (7359-14-0)

Guidance literature:

With Iodine monochloride; silver nitrate; In pyridine; chloroform; at 20 ℃; for 2h;

DOI:10.1080/00397910701771199

Reference yield: 90.0%

2-hydroxy-5-iodo-3-methoxybenzaldehyde (7359-14-0) + methyl iodide (74-88-4) → 5-iodo-2,3-dimethoxybenzaldehyde (7396-66-9)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 68 ℃; for 16h;

DOI:10.1080/00397910701771199

Reference yield: 88.0%

2-hydroxy-5-iodo-3-methoxybenzaldehyde (7359-14-0) + ethyl acrylate (140-88-5,9003-32-1) → C13H14O5

Guidance literature:

With palladium diacetate; triethylamine; tris-(o-tolyl)phosphine; In acetonitrile; at 90 ℃; for 9h; Inert atmosphere;

DOI:10.1002/ejoc.201600154

upstream raw materials:

3-methoxy-2-hydroxybenzaldehyde

Downstream raw materials:

4-Iod-2-methoxy-5-(2-nitro-vinyl)-phenol

2-Acetoxy-1-diacetoxymethyl-3-methoxy-5-jod-benzol

(2-Formyl-4-jod-6-methoxy-phenoxy)essigsaeure-ethylester

1,2-Bis-(5-jod-2-hydroxy-3-methoxy-benzylidenamino)-ethan