1-ETHYL-4-HYDROXY-6-METHYLPYRIDIN-2(1H)-ONE

Base Information

• Chemical Name: 1-ETHYL-4-HYDROXY-6-METHYLPYRIDIN-2(1H)-ONE
• CAS No.: 61296-13-7
• Molecular Formula: C8H11 N O2
• Molecular Weight: 153.181
• Hs Code.: 2933399090
• Mol file: 61296-13-7.mol

Synonyms:2(1)-Pyridone,1-ethyl-4-hydroxy-6-methyl- (4CI); 4-Hydroxy-6-methyl-N-ethyl-2(1H)-pyridinone;NSC 142144

Chemical Property of 1-ETHYL-4-HYDROXY-6-METHYLPYRIDIN-2(1H)-ONE

Chemical Property:

• Vapor Pressure: 0.00349mmHg at 25°C
• Boiling Point: 250.2°C at 760 mmHg
• Flash Point: 105.1°C
• PSA: 42.23000
• Density: 1.168g/cm³
• LogP: 0.88220

Purity/Quality:

97% ^*data from raw suppliers

1-Ethyl-4-hydroxy-6-methyl-1H-pyridin-2-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-ETHYL-4-HYDROXY-6-METHYLPYRIDIN-2(1H)-ONE

There total 1 articles about 1-ETHYL-4-HYDROXY-6-METHYLPYRIDIN-2(1H)-ONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

4-hydroxy-6-methyl-2-pyron (675-10-5) + ethylamine (75-04-7,85404-22-4) → 1-ethyl-4-hydroxy-6-methyl-pyridine-2(1H)-one (61296-13-7)

Guidance literature:

In water; at 100 ℃;

DOI:10.1016/j.tetlet.2016.02.043

Reference yield: 92.0%

4-fluorobenzaldehyde (459-57-4) + 1-ethyl-4-hydroxy-6-methyl-pyridine-2(1H)-one (61296-13-7) + malononitrile (109-77-3) → 2-amino-6-ethyl-4-(4-fluorophenyl)-5,6-dihydro-7-methyl-5-oxo-4H-pyrano[3,2-c]pyridine-3-carbonitrile (880794-92-3)

Guidance literature:

at 80 ℃; for 2h; Ionic liquid;

DOI:10.1016/j.bmcl.2009.12.102

Reference yield: 91.0%

4-nitrobenzaldehdye (555-16-8) + dimedone (126-81-8) + 1-ethyl-4-hydroxy-6-methyl-pyridine-2(1H)-one (61296-13-7) → 2-ethyl-3,7,7-trimethyl-10-(4-nitrophenyl)-6,7,8,10-tetrahydro-1H-chromeno[3,2-c]pyridine-1,9(2H)-dione

Guidance literature:

With tin(II) chloride dihdyrate; In ethanol; at 70 ℃; for 3h;

DOI:10.1002/jhet.4404

upstream raw materials:

4-hydroxy-6-methyl-2-pyron

ethylamine

Downstream raw materials:

4-[(2-bromo-5-methoxybenzyl)oxy]-1-ethyl-6-methyl-1,2-dihydropyridin-2-one

4-[(2-bromobenzyl)oxy]-1-ethyl-6-methyl-1,2-dihydropyridin-2-one

2-amino-6-ethyl-5,6-dihydro-4-(4-methylphenyl)-7-methyl-5-oxo-4H-pyrano[3,2-c]pyridine-3-carbonitrile

2-amino-6-ethyl-4-(4-fluorophenyl)-5,6-dihydro-7-methyl-5-oxo-4H-pyrano[3,2-c]pyridine-3-carbonitrile

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