2-(8-Benzyloxy-2-cyclopropyl-3-(o-phenylbenzyl)-indolizin-1-yl)acetamide

Base Information

Chemical Name:2-(8-Benzyloxy-2-cyclopropyl-3-(o-phenylbenzyl)-indolizin-1-yl)acetamide
CAS No.:177558-61-1
Molecular Formula:C₃₃H₃₀N₂O₂
Molecular Weight:486.613
Hs Code.:

Synonyms:2-(8-Benzyloxy-2-cyclopropyl-3-(o-phenylbenzyl)-indolizin-1-yl)acetamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-(8-Benzyloxy-2-cyclopropyl-3-(o-phenylbenzyl)-indolizin-1-yl)acetamide

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Technology Process of 2-(8-Benzyloxy-2-cyclopropyl-3-(o-phenylbenzyl)-indolizin-1-yl)acetamide

There total 10 articles about 2-(8-Benzyloxy-2-cyclopropyl-3-(o-phenylbenzyl)-indolizin-1-yl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

: 177558-61-1
2-(8-Benzyloxy-2-cyclopropyl-3-(o-phenylbenzyl)-indolizin-1-yl)acetamide

Guidance literature:

Reference yield: 37.9%

: 177558-56-4
2-(8-Benzyloxy-2-cyclopropyl-3-(o-phenylbenzoyl)-indolizin-1-yl)acetamide

: 177558-61-1
2-(8-Benzyloxy-2-cyclopropyl-3-(o-phenylbenzyl)-indolizin-1-yl)acetamide

Guidance literature:: With aluminium trichloride; borane; tert-butylamine; In dichloromethane; for 5h;
DOI:10.1021/jm960395q

Reference yield:

: 139745-90-7
(E)-ethyl 3-(3-(benzyloxy)-2-pyridinyl)propenoate

: 177558-61-1
2-(8-Benzyloxy-2-cyclopropyl-3-(o-phenylbenzyl)-indolizin-1-yl)acetamide

Guidance literature:: Multi-step reaction with 6 steps

1: 47 percent / H₂ / 10percent Pd/C / ethyl acetate

2: 94.7 percent / aq. NH₄OH / Ambient temperature

3: 68.2 percent / K₂CO₃ / butan-2-one / 9 h / Heating

4: 30.8 percent / NaHCO₃ / butan-2-one / Heating

5: 56.6 percent / benzene / 4 h / Heating

6: 37.9 percent / BH₃, t-BuNH₂, AlCl₃ / CH₂Cl₂ / 5 h

With ammonium hydroxide; aluminium trichloride; borane; hydrogen; sodium hydrogencarbonate; potassium carbonate; tert-butylamine; palladium on activated charcoal; In dichloromethane; ethyl acetate; butanone; benzene;
DOI:10.1021/jm960395q