2-(4-BROMOPHENYL)-PROPANEDIOIC ACID 1,3-BIS-T-BUTYL ESTER

Base Information

Chemical Name:2-(4-BROMOPHENYL)-PROPANEDIOIC ACID 1,3-BIS-T-BUTYL ESTER
CAS No.:641638-37-1
Molecular Formula:C17H23 Br O4
Molecular Weight:371.271
Hs Code.:
Mol file:641638-37-1.mol

Synonyms:Propanedioicacid, (4-bromophenyl)-, bis(1,1-dimethylethyl) ester (9CI)

Suppliers and Price of 2-(4-BROMOPHENYL)-PROPANEDIOIC ACID 1,3-BIS-T-BUTYL ESTER

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
2-(4-BROMOPHENYL)PROPANEDIOIC ACID-1,3-BIS-TERT-BUTYL ESTER 95.00%
5MG
$ 499.11

Total 2 raw suppliers

Chemical Property of 2-(4-BROMOPHENYL)-PROPANEDIOIC ACID 1,3-BIS-T-BUTYL ESTER

Chemical Property:

PSA：52.60000
LogP:4.21610

Purity/Quality:

99% ^*data from raw suppliers

2-(4-BROMOPHENYL)PROPANEDIOIC ACID-1,3-BIS-TERT-BUTYL ESTER 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 2-(4-BROMOPHENYL)-PROPANEDIOIC ACID 1,3-BIS-T-BUTYL ESTER

There total 1 articles about 2-(4-BROMOPHENYL)-PROPANEDIOIC ACID 1,3-BIS-T-BUTYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 541-16-2
t-butyl malonate

: 589-87-7
1,4-bromoiodobenzene

: 641638-37-1
2-(4-bromophenyl)propane-1,3-dioic acid bis(1,1-dimethylethyl) ester

Guidance literature:: t-butyl malonate; With N,N,N,N,N,N-hexamethylphosphoric triamide; sodium hydride; In 1,4-dioxane; at 20 ℃; for 1h;

1,4-bromoiodobenzene; With copper(I) bromide; In 1,4-dioxane; for 3h; Heating;
DOI:10.1021/jm030510e

Reference yield: 87.0%

: 259529-54-9
(4S)-3-(1-oxo-2-propen-1-yl)-4-phenyl-1,3-oxazolidin-2-one

: 641638-37-1
2-(4-bromophenyl)propane-1,3-dioic acid bis(1,1-dimethylethyl) ester

: 641638-38-2
2-{4-[(1E)-3-((4S)-2-oxo-4-phenyl-(1,3-oxazolidin-3-yl))-3-oxoprop-1-enyl]phenyl}propane-1,3-dioic acid bis(1,1-dimethylethyl) ester

Guidance literature:: With palladium diacetate; triethylamine; tris-(o-tolyl)phosphine; for 16h; Heating;
DOI:10.1021/jm030510e

Reference yield:

: 641638-37-1
2-(4-bromophenyl)propane-1,3-dioic acid bis(1,1-dimethylethyl) ester

: 641638-40-6
2-[4-(3-((4S)-2-oxo-4-phenyl)-(1,3-oxazolidin-3-yl))]-(1S,2S)-2-{[(tert-butyl)oxycarbonylmethyl-3-oxo-1-vinylpropyl]phenyl}propane-1,3-dioic acid bis(1,1-dimethylethyl) ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: 87 percent / Et₃N; Pd(OAc)2; (o-tolyl)3P / 16 h / Heating

2.1: PhSCu / diethyl ether; tetrahydrofuran / 0.33 h / -40 °C

2.2: 58 percent / tetrahydrofuran; diethyl ether / 3 h / -40 °C

3.1: N-sodiohexamethyldisilazane / tetrahydrofuran / 1 h / -78 °C

3.2: 53 percent / tetrahydrofuran / 4 h / -78 °C

With palladium diacetate; sodium hexamethyldisilazane; copper(I) thiophenolate; triethylamine; tris-(o-tolyl)phosphine; In tetrahydrofuran; diethyl ether;
DOI:10.1021/jm030510e