METHYL (2-METHYL-1H-PYRROLO[2,3B] PYRIDINE 3-YL) ACETIC ACID

Base Information

• Chemical Name: METHYL (2-METHYL-1H-PYRROLO[2,3B] PYRIDINE 3-YL) ACETIC ACID
• CAS No.: 7546-50-1
• Molecular Formula: C10H10N2O2
• Molecular Weight: 190.202
• Hs Code.: 2933990090
• Mol file: 7546-50-1.mol

Synonyms:METHYL (2-METHYL-1H-PYRROLO[2,3B] PYRIDINE 3-YL) ACETIC ACID;1H-Pyrrolo[2,3-b]pyridine-3-acetic acid, 2-methyl-

Chemical Property of METHYL (2-METHYL-1H-PYRROLO[2,3B] PYRIDINE 3-YL) ACETIC ACID

Chemical Property:

• Melting Point: 250.6-251.8 °C
• Refractive Index: 1.681
• Boiling Point: 498.6±37.0 °C(Predicted)
• PKA: 4.25±0.10(Predicted)
• PSA: 65.98000
• Density: 1.37g/cm³
• LogP: 1.49840
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

2-Methyl-7-aza-3-indolylaceticAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: An azaindole derivative.

Technology Process of METHYL (2-METHYL-1H-PYRROLO[2,3B] PYRIDINE 3-YL) ACETIC ACID

There total 1 articles about METHYL (2-METHYL-1H-PYRROLO[2,3B] PYRIDINE 3-YL) ACETIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-methyl-1H-pyrrolo[2,3-b]pyridine (23612-48-8) → 2-(2-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)acetic acid (7546-50-1)

Guidance literature:

Multi-step reaction with 3 steps

1: butan-1-ol / Reflux

2: hydrogenchloride / water / Reflux

3: hydrogenchloride / water

With hydrogenchloride; In water; butan-1-ol; 1: |Mannich Aminomethylation;

DOI:10.1358/dof.2018.043.08.2832262

Reference yield:

N-(3,5-dimethyl-1-phenyl-1H-pyrazol-4-yl)-2-hydroxyacetamide + 2-(2-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)acetic acid (7546-50-1) → 2-((3,5-dimethyl-1-phenyl-1H-pyrazol-4-yl)amino)-2-oxoethyl 2-(2-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)acetate

Guidance literature:

With dmap; dicyclohexyl-carbodiimide; In acetonitrile; at 20 ℃; for 3h;

DOI:10.1021/acs.jmedchem.8b01106

Reference yield:

2-(2-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)acetic acid (7546-50-1) → 2-[2-methyl-1-[[4-methylsulfonyl-2-(trifluoromethyl)phenyl]methyl]pyrrolo[2,3-b]pyridine-3-yl]acetic acid (872365-14-5)

Guidance literature:

Multi-step reaction with 2 steps

1: sulfuric acid

2: caesium carbonate; magnesium sulfate / acetone / Reflux

With sulfuric acid; magnesium sulfate; caesium carbonate; In acetone;

DOI:10.1358/dof.2018.043.08.2832262

upstream raw materials:

2-methyl-1H-pyrrolo[2,3-b]pyridine

Downstream raw materials:

2-[2-methyl-1-[[4-methylsulfonyl-2-(trifluoromethyl)phenyl]methyl]pyrrolo[2,3-b]pyridine-3-yl]acetic acid

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