1-Isoquinolineacetic acid,1,2,3,4-tetrahydro-6-hydroxy-,ethyl ester

Base Information

Chemical Name:1-Isoquinolineacetic acid,1,2,3,4-tetrahydro-6-hydroxy-,ethyl ester
CAS No.:649722-04-3
Molecular Formula:C₁₃H₁₇NO₃
Molecular Weight:235.283
Hs Code.:
Mol file:649722-04-3.mol

Synonyms:1-Isoquinolineacetic acid,1,2,3,4-tetrahydro-6-hydroxy-,ethyl ester

Suppliers and Price of 1-Isoquinolineacetic acid,1,2,3,4-tetrahydro-6-hydroxy-,ethyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-Isoquinolineacetic acid,1,2,3,4-tetrahydro-6-hydroxy-,ethyl ester

Chemical Property:

Boiling Point:390.7±42.0 °C(Predicted)
PKA:9.82±0.40(Predicted)
PSA：58.56000
Density:1.148±0.06 g/cm3(Predicted)
LogP:1.86100

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

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Technology Process of 1-Isoquinolineacetic acid,1,2,3,4-tetrahydro-6-hydroxy-,ethyl ester

There total 6 articles about 1-Isoquinolineacetic acid,1,2,3,4-tetrahydro-6-hydroxy-,ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 92501-46-7
(6-methoxy-1,2,3,4-tetrahydroisoquinolin-1-yl)acetic acid ethyl ester

: 649722-04-3
(6-hydroxy-1,2,3,4-tetrahydro-isoquinolin-1-yl)-acetic acid ethyl ester

Guidance literature:: With boron tribromide; In dichloromethane; at 20 ℃; for 3h;
DOI:10.1016/S0968-0896(03)00452-8

Reference yield:

: 106840-17-9
N-(3-methoxy-phenethyl)-malonamic acid ethyl ester

: 649722-04-3
(6-hydroxy-1,2,3,4-tetrahydro-isoquinolin-1-yl)-acetic acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 7.56 g / POCl₃ / 4 h / 80 °C

2: 4.88 g / H₂; acetic acid / PtO₂ / 3 h / 20 °C

3: 2.10 g / boron tribromide / CH₂Cl₂ / 3 h / 20 °C

With hydrogen; boron tribromide; acetic acid; trichlorophosphate; platinum(IV) oxide; In dichloromethane; 1: Bischler-Napieralski reaction;
DOI:10.1016/S0968-0896(03)00452-8

Reference yield:

: 2039-67-0
2-(3-methoxyphenyl)-1-ethanamine

: 649722-04-3
(6-hydroxy-1,2,3,4-tetrahydro-isoquinolin-1-yl)-acetic acid ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 63 percent / K₂CO₃ / CH₂Cl₂ / 0.5 h / 0 °C

2: 7.56 g / POCl₃ / 4 h / 80 °C

3: 4.88 g / H₂; acetic acid / PtO₂ / 3 h / 20 °C

4: 2.10 g / boron tribromide / CH₂Cl₂ / 3 h / 20 °C

With hydrogen; boron tribromide; potassium carbonate; acetic acid; trichlorophosphate; platinum(IV) oxide; In dichloromethane; 2: Bischler-Napieralski reaction;
DOI:10.1016/S0968-0896(03)00452-8