1-(Methylsulfonyl)piperidin-4-amine hydrochloride

Base Information

• Chemical Name: 1-(Methylsulfonyl)piperidin-4-amine hydrochloride
• CAS No.: 651057-01-1
• Molecular Formula: C6H14N2O2S^.HCl
• Molecular Weight: 214.716
• Hs Code.: 29339900
• European Community (EC) Number: 825-502-4
• DSSTox Substance ID: DTXSID40589420
• Mol file: 651057-01-1.mol

Synonyms:1-(methylsulfonyl)piperidin-4-amine hydrochloride;651057-01-1;1-methanesulfonylpiperidin-4-amine hydrochloride;1-methylsulfonylpiperidin-4-amine;hydrochloride;MFCD08690153;1-Methanesulfonyl-piperidin-4-ylamine hydrochloride;1-(methylsulfonyl)piperidin-4-amine HCl;1-(Methylsulfonyl)piperidin-4-amine, HCl;4-Piperidinamine, 1-(methylsulfonyl)-, monohydrochloride;1-methylsulfonylpiperidin-4-amine hydrochloride;4-Amino-1-(methylsulfonyl)piperidine Hydrochloride;SCHEMBL928103;AMY6031;DTXSID40589420;BASBDQBWDDKEDK-UHFFFAOYSA-N;BBB05701;AKOS015849485;CS-W021256;PB12553;1-(Methylsulfonyl)-4-Piperidinamine HCl;DS-13494;SY020447;EN300-26205;1-(Methylsulfonyl)piperidin-4-aminehydrochloride;1-(Methylsulfonyl)piperidin-4-amine'hydrochloride;A834975;1-methanesulphonyl-piperidin-4-ylamine hydrochloride;Q-103040;F8889-5285;Z221425100;4-AMINO-1-(METHANESULFONYL)PIPERIDINE HYDROCHLORIDE;1-(Methanesulfonyl)piperidin-4-amine--hydrogen chloride (1/1);1-(Methylsulfonyl)piperidin-4-amine hydrochloride

Chemical Property of 1-(Methylsulfonyl)piperidin-4-amine hydrochloride

Chemical Property:

• Boiling Point: 328.3 °C at 760 mmHg
• Flash Point: 152.3 °C
• PSA: 71.78000
• LogP: 1.89010
• Storage Temp.: Sealed in dry,Room Temperature
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 1
• Exact Mass: 214.0542766
• Heavy Atom Count: 12
• Complexity: 211

Purity/Quality:

99.0% ^*data from raw suppliers

1-(Methylsulfonyl)piperidin-4-amineHydrochloride ^*data from reagent suppliers

Safty Information:

• Safety Statements: 24/25

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CS(=O)(=O)N1CCC(CC1)N.Cl

Technology Process of 1-(Methylsulfonyl)piperidin-4-amine hydrochloride

There total 2 articles about 1-(Methylsulfonyl)piperidin-4-amine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(1-methanesulfonyl-piperidin-4-yl)carbamic acid tert-butyl ester (287953-38-2) → 1-(methylsulfonyl)piperidin-4-amine hydrochloride (651057-01-1)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 24h;

Reference yield:

methanesulfonyl chloride (124-63-0) + (piperidin-4-yl)carbamic acid tert-butyl ester (73874-95-0) → 1-(methylsulfonyl)piperidin-4-amine hydrochloride (651057-01-1)

Guidance literature:

methanesulfonyl chloride; (piperidin-4-yl)carbamic acid tert-butyl ester; With triethylamine; In dichloromethane; for 4h;

With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 1h;

DOI:10.1016/j.bmcl.2020.127426

Reference yield: 53.0%

1-(methylsulfonyl)piperidin-4-amine hydrochloride (651057-01-1) + N-[3-(chloromethyl)-8-methylquinolin-7-yl]-4-(cyclopropylmethoxy)benzamide hydrochloride (1018856-64-8) → 4-(cyclopropylmethoxy)-N-[8-methyl-3-({[1-(methylsulfonyl)piperidin-4-yl]amino}methyl)quinolin-7-yl]benzamide (1190043-78-7)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 60 ℃;

upstream raw materials:

(1-methanesulfonyl-piperidin-4-yl)carbamic acid tert-butyl ester

methanesulfonyl chloride

(piperidin-4-yl)carbamic acid tert-butyl ester

Downstream raw materials:

4-(cyclopropylmethoxy)-N-[8-methyl-3-({[1-(methylsulfonyl)piperidin-4-yl]amino}methyl)quinolin-7-yl]benzamide

Refernces

• 1、 -. "HETEROCYCLIC COMPOUND". Page/Page column 44-45. . Retrieved 2010/12/30.