N-(4-CHLOROPHENYL)-4-METHOXYBENZAMIDE

Base Information

• Chemical Name: N-(4-CHLOROPHENYL)-4-METHOXYBENZAMIDE
• CAS No.: 7595-61-1
• Molecular Formula: C14H12 Cl N O2
• Molecular Weight: 261.708
• Hs Code.: 2924299090
• Mol file: 7595-61-1.mol

Synonyms:p-Anisanilide,4'-chloro- (7CI); 4'-Chloro-4-methoxybenzanilide; 4'-Chloro-p-anisanilide;N-(4-Chlorophenyl)-4-methoxybenzamide; N-(p-Chlorophenyl)-p-methoxybenzamide;NSC 404052

Chemical Property of N-(4-CHLOROPHENYL)-4-METHOXYBENZAMIDE

Chemical Property:

• Vapor Pressure: 0.000185mmHg at 25°C
• Boiling Point: 328.8°C at 760 mmHg
• Flash Point: 152.7°C
• PSA: 38.33000
• Density: 1.281g/cm³
• LogP: 3.67390

Purity/Quality:

99% ^*data from raw suppliers

N-(4-CHLOROPHENYL)-4-METHOXYBENZAMIDE AldrichCPR ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-(4-CHLOROPHENYL)-4-METHOXYBENZAMIDE

There total 16 articles about N-(4-CHLOROPHENYL)-4-METHOXYBENZAMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

4-chloro-aniline (106-47-8) + 4-methoxy-benzoyl chloride (100-07-2) → N-(4-chlorophenyl)-4-methoxybenzamide (7595-61-1)

Guidance literature:

With samarium; In acetonitrile; at 20 ℃; for 4h;

DOI:10.1016/j.tetlet.2010.09.048

Reference yield: 84.0%

4-chloro-aniline (106-47-8) + 4-methoxybenzoic acid (100-09-4) → N-(4-chlorophenyl)-4-methoxybenzamide (7595-61-1)

Guidance literature:

With triethylamine; trichloromethyl chloroformate; In dichloromethane; at 20 ℃; for 0.5h;

DOI:10.1080/00304940509354888

Reference yield: 81.0%

4-Methoxy-benzoic acid 4,5-dimethyl-[1,2,3]triazol-1-yl ester (122081-23-6) + 4-chloro-aniline (106-47-8) → N-(4-chlorophenyl)-4-methoxybenzamide (7595-61-1) + 4,5-dimethyl-1,2,3-triazol-1-ol (122081-30-5)

Guidance literature:

With triethylamine; In 1,4-dioxane; for 4h; Ambient temperature;

DOI:10.1039/P19890000619

upstream raw materials:

4-Methoxy-benzoic acid 4,5-dimethyl-[1,2,3]triazol-1-yl ester

4-chloro-aniline

4-chlorobenzonitrile

p-methoxybenzylnitrile

Downstream raw materials:

6-chloro-2-(4-methoxyphenyl)benzo[d]oxazole

(Z)-4-chloro-N-(1-(4-methoxyphenyl)-3-(trimethylsilyl)prop-2-ynylidene)aniline

6-chloro-2-(4-methoxyphenyl)benzo[d]thiazole

N-(4-chlorophenyl)-4-methoxybenzothioamide

Refernces

• 1、 Lang, Xian-Dong,He, Liang-Nian. "Integration of co2 reduction with subsequent carbonylation: Towards extending chemical utilization of co2". . p. , 2062. Retrieved 2018/10/20.
• 2、 Zhao, Zhenguang,Peng, Zhiyuan,Zhao, Yongli,Liu, Hao,Li, Chongnan,Zhao, Junfeng. "Hypervalent Iodine-Mediated Oxidative Rearrangement of N-H Ketimines: An Umpolung Approach to Amides". . p. 11848 - 11853. Retrieved 2017/11/28.