N-CYCLOHEXYL-4-PIPERIDINECARBOXAMIDE HYDROCHLORIDE

Base Information

• Chemical Name: N-CYCLOHEXYL-4-PIPERIDINECARBOXAMIDE HYDROCHLORIDE
• CAS No.: 63214-55-1
• Molecular Formula: C₁₂H₂₂N₂O
• Molecular Weight: 210.319
• Hs Code.: 2933399090

Synonyms:N-CYCLOHEXYL-4-PIPERIDINECARBOXAMIDE HYDROCHLORIDE

Chemical Property of N-CYCLOHEXYL-4-PIPERIDINECARBOXAMIDE HYDROCHLORIDE

Chemical Property:

• Boiling Point: 400.2±34.0 °C(Predicted)
• PKA: 15.65±0.20(Predicted)
• PSA: 41.13000
• Density: 1.03±0.1 g/cm3(Predicted)
• LogP: 2.95660

Purity/Quality:

97% ^*data from raw suppliers

N-Cyclohexylpiperidine-4-carboxamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: N-Cyclohexylpiperidine-4-carboxamide

Technology Process of N-CYCLOHEXYL-4-PIPERIDINECARBOXAMIDE HYDROCHLORIDE

There total 6 articles about N-CYCLOHEXYL-4-PIPERIDINECARBOXAMIDE HYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

tert-butyl 4-(cyclohexylcarbamoyl)piperidine-1-carboxylate (757949-48-7) → piperidine-4-carboxylic acid cyclohexylamide (63214-55-1)

Guidance literature:

With trifluoroacetic acid; at 20 ℃; for 24h; Inert atmosphere;

DOI:10.1016/j.ejmech.2014.12.018

Reference yield:

N-[(tert-butoxy)carbonyl]piperidine-4-carboxylic acid (84358-13-4,174286-31-8) → piperidine-4-carboxylic acid cyclohexylamide (63214-55-1)

Guidance literature:

Multi-step reaction with 3 steps

1: pyridine; thionyl chloride / dichloromethane / 0.5 h / 20 °C / Inert atmosphere

2: triethylamine; dmap / dichloromethane / 20 °C / Inert atmosphere

3: trifluoroacetic acid / 24 h / 20 °C / Inert atmosphere

With pyridine; dmap; thionyl chloride; triethylamine; trifluoroacetic acid; In dichloromethane;

DOI:10.1016/j.ejmech.2014.12.018

Reference yield:

cyclohexylamine (108-91-8,157973-60-9) → piperidine-4-carboxylic acid cyclohexylamide (63214-55-1)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine; dmap / dichloromethane / 20 °C / Inert atmosphere

2: trifluoroacetic acid / 24 h / 20 °C / Inert atmosphere

With dmap; triethylamine; trifluoroacetic acid; In dichloromethane;

DOI:10.1016/j.ejmech.2014.12.018

upstream raw materials:

tert-butyl 4-(cyclohexylcarbamoyl)piperidine-1-carboxylate

N-[(tert-butoxy)carbonyl]piperidine-4-carboxylic acid

cyclohexylamine

isonipecotic acid

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