3-Methyl-1-pyridin-2-yl-piperazine

Base Information

• Chemical Name: 3-Methyl-1-pyridin-2-yl-piperazine
• CAS No.: 63286-11-3
• Molecular Formula: C10H15N3
• Molecular Weight: 177.2462
• DSSTox Substance ID: DTXSID80474386
• Nikkaji Number: J1.789.631H
• Mol file: 63286-11-3.mol

Synonyms:63286-11-3;3-methyl-1-pyridin-2-yl-piperazine;3-methyl-1-pyridin-2-ylpiperazine;3-METHYL-1-(PYRIDIN-2-YL)PIPERAZINE;SCHEMBL709716;DTXSID80474386;MFCD06858505;AKOS011768026;AC-1511;SB45849;FT-0712214;A26633;F13591

Chemical Property of 3-Methyl-1-pyridin-2-yl-piperazine

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.528
• Boiling Point: 317.575 °C at 760 mmHg
• Flash Point: 145.864 °C
• PSA: 28.16000
• Density: 1.037 g/cm³
• LogP: 1.27350
• XLogP3: 1.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 177.126597491
• Heavy Atom Count: 13
• Complexity: 160

Purity/Quality:

97% ^*data from raw suppliers

3-Methyl-1-(pyridin-2-yl)piperazine 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1CN(CCN1)C2=CC=CC=N2

Technology Process of 3-Methyl-1-pyridin-2-yl-piperazine

There total 2 articles about 3-Methyl-1-pyridin-2-yl-piperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

2-chloropyridine (109-09-1) + (RS)-2-methylpiperazine (109-07-9) → 3-methyl-1-(2-pyridinyl)piperazine (63286-11-3)

Guidance literature:

(RS)-2-methylpiperazine; With [2,2]bipyridinyl; nickel diacetate; sodium hydride; tert-Amyl alcohol; In tetrahydrofuran; at 65 ℃; for 2h;

2-chloropyridine; With styrene; In tetrahydrofuran; at 65 ℃; for 8.5h;

DOI:10.1016/S0040-4020(02)00750-0

Reference yield:

→ 3-methyl-1-(2-pyridinyl)piperazine (63286-11-3)

Guidance literature:

2-Methylpiperazin, 2-Chlorpyridin;

Reference yield: 66.0%

N-(4-nitrophenyl) acrylamide (7766-38-3) + 3-methyl-1-(2-pyridinyl)piperazine (63286-11-3) → 3-(2-Methyl-4-pyridin-2-yl-piperazin-1-yl)-N-(4-nitro-phenyl)-propionamide (86523-98-0)

Guidance literature:

In toluene; Heating;

DOI:10.1021/jm00384a002

upstream raw materials:

2-chloropyridine

(RS)-2-methylpiperazine

Downstream raw materials:

3-(2-Methyl-4-pyridin-2-yl-piperazin-1-yl)-N-(4-nitro-phenyl)-propionamide

N-(4-Amino-phenyl)-3-(2-methyl-4-pyridin-2-yl-piperazin-1-yl)-propionamide

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