Ethyl 1-benzyl-4-methylpiperazine-2-carboxylate

Base Information

Chemical Name:Ethyl 1-benzyl-4-methylpiperazine-2-carboxylate
CAS No.:63285-59-6
Molecular Formula:C15H22N2O2
Molecular Weight:262.352
Hs Code.:
DSSTox Substance ID:DTXSID20441830
Mol file:63285-59-6.mol

Synonyms:63285-59-6;ETHYL 1-BENZYL-4-METHYLPIPERAZINE-2-CARBOXYLATE;4-methyl-1-(phenylmethyl)-2-piperazinecarboxylic acid ethyl ester;ETHYL1-BENZYL-4-METHYLPIPERAZINE-2-CARBOXYLATE;SCHEMBL3306018;ethyl 4-methyl-1-(phenylmethyl)piperazine-2-carboxylate;DTXSID20441830;ONEHQIOWNHNCLM-UHFFFAOYSA-N;AB2830;MFCD09037897;AS-44659;A834313;1-benzyl-4-methylpiperazine-2-carboxylic acid, ethyl ester

Suppliers and Price of Ethyl 1-benzyl-4-methylpiperazine-2-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
Ethyl1-benzyl-4-methylpiperazine-2-carboxylate 97%
10g
$ 805.00

American Custom Chemicals Corporation
ETHYL-1-BENZYL-4-METHYLPIPERAZINE-2-CARBOXYLATE 95.00%
5MG
$ 505.81

Total 4 raw suppliers

Chemical Property of Ethyl 1-benzyl-4-methylpiperazine-2-carboxylate

Chemical Property:

PSA：32.78000
LogP:1.24150
XLogP3:1.9
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:5
Exact Mass:262.168127949
Heavy Atom Count:19
Complexity:290

Purity/Quality:

97% ^*data from raw suppliers

Ethyl1-benzyl-4-methylpiperazine-2-carboxylate 97% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CCOC(=O)C1CN(CCN1CC2=CC=CC=C2)C

Technology Process of Ethyl 1-benzyl-4-methylpiperazine-2-carboxylate

There total 8 articles about Ethyl 1-benzyl-4-methylpiperazine-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 63285-59-6
ethyl 1-benzyl-4-methylpiperazine-2-carboxylate

Guidance literature:: With potassium carbonate; In acetonitrile; at 70 ℃; for 12h;

Reference yield: 72.0%

: 1-benzyl-piperazine-2-carboxylic acid ethyl ester bis(trifluoroacetate)

: 74-88-4
methyl iodide

: 63285-59-6
ethyl 1-benzyl-4-methylpiperazine-2-carboxylate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 20 ℃;

Reference yield:

: ethyl 1,4-bis(phenylmethyl)-2-piperazine carboxylate dihydrochloride

: 63285-59-6
ethyl 1-benzyl-4-methylpiperazine-2-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: 91 percent / H₂ / 10percent Pd/C / ethanol / 40 °C

2: 80 percent / Et₃N / CH₂Cl₂ / -10 °C

3: K₂CO₃, KI / acetone / 15 h / Ambient temperature

4: conc. HCl / acetone / 3 h / Ambient temperature

5: HCO₂H / methanol; H₂O / 20 h / Heating

With hydrogenchloride; formic acid; hydrogen; potassium carbonate; triethylamine; potassium iodide; palladium on activated charcoal; In methanol; ethanol; dichloromethane; water; acetone;
DOI:10.1021/jm9608624