Pyrimidine, 2,4-dimethyl-6-phenyl- (9CI)

Base Information

• Chemical Name: Pyrimidine, 2,4-dimethyl-6-phenyl- (9CI)
• CAS No.: 64571-30-8
• Molecular Formula: C12H12 N2
• Molecular Weight: 184.241
• Mol file: 64571-30-8.mol

Synonyms:2,4-Dimethyl-6-phenylpyrimidine

Chemical Property of Pyrimidine, 2,4-dimethyl-6-phenyl- (9CI)

Chemical Property:

• PSA: 25.78000
• LogP: 2.76040

Purity/Quality:

97% ^*data from raw suppliers

2,4-Dimethyl-6-phenylpyrimidine 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Pyrimidine, 2,4-dimethyl-6-phenyl- (9CI)

There total 21 articles about Pyrimidine, 2,4-dimethyl-6-phenyl- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

phenylacetylene (536-74-3) + acetonitrile (75-05-8,26809-02-9) → 2,4-dimethyl-6-phenylpyrimidine (64571-30-8)

Guidance literature:

With trifluorormethanesulfonic acid; for 24h; Ambient temperature;

DOI:10.1055/s-1990-27040

Reference yield: 90.0%

acetophenone (98-86-2) + acetonitrile (75-05-8,26809-02-9) → 2,4-dimethyl-6-phenylpyrimidine (64571-30-8)

Guidance literature:

With trifluoromethylsulfonic anhydride; In 1,2-dichloro-ethane; for 24h; Heating;

DOI:10.1021/jo00031a062

Reference yield: 83.0%

(2Z)-3-amino-1-phenylbut-2-en-1-one (23652-90-6) + acetonitrile (75-05-8,26809-02-9) → 2,4-dimethyl-6-phenylpyrimidine (64571-30-8)

Guidance literature:

With sodium hydroxide; copper dichloride; at 120 ℃; for 16h; Schlenk technique; Inert atmosphere;

DOI:10.1021/acs.orglett.8b01324

upstream raw materials:

4-chloro-2,6-dimethylpyrimidine

tributylphenylstannane

4-methyl-6-phenyl-1,2,3-triazine

2,4-dimethylbenzothieno<3,2-d>pyrimidine

Downstream raw materials:

2-methyl-6-phenylpyrimidine-4-carbaldehyde

6-phenyl-2,4(E,E)-distyrylpyrimidine

2-methyl-6-phenyl-4(E)-styrylpyrimidine

Refernces

• 1、 Shen, Jian,Meng, Xu. "Selective synthesis of pyrimidines from cinnamyl alcohols and amidines using the heterogeneous OMS-2 catalyst". . . Retrieved 2019/11/14.
• 2、 Su, Lebin,Sun, Kang,Pan, Neng,Liu, Long,Sun, Mengli,Dong, Jianyu,Zhou, Yongbo,Yin, Shuang-Feng. "Cyclization of Ketones with Nitriles under Base: A General and Economical Synthesis of Pyrimidines". supporting information. p. 3399 - 3402. Retrieved 2018/06/11.