1H-Indol-7-ol,2,3-dihydro-6-methoxy-(9CI)

Base Information

Chemical Name:1H-Indol-7-ol,2,3-dihydro-6-methoxy-(9CI)
CAS No.:70837-64-8
Molecular Formula:C9H11NO2
Molecular Weight:165.19
Hs Code.:
Mol file:70837-64-8.mol

Synonyms:1H-Indol-7-ol,2,3-dihydro-6-methoxy-(9CI)

Suppliers and Price of 1H-Indol-7-ol,2,3-dihydro-6-methoxy-(9CI)

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemicals and raw materials
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price

Total 2 raw suppliers

Chemical Property of 1H-Indol-7-ol,2,3-dihydro-6-methoxy-(9CI)

Chemical Property:

Melting Point:106.6 °C
PSA：41.49000
LogP:1.50680

Purity/Quality:: 95% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

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Technology Process of 1H-Indol-7-ol,2,3-dihydro-6-methoxy-(9CI)

There total 7 articles about 1H-Indol-7-ol,2,3-dihydro-6-methoxy-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 1448661-52-6
6-methoxy-7-(2-mesyloxyethoxy)indole

: 70837-64-8
6-methoxy-7-hydroxy-2,3-dihydroindole

Guidance literature:: With 5%-palladium/activated carbon; hydrogen; acetic acid; at 20 ℃; for 16h;
DOI:10.1021/jm400867d

Reference yield:

: 153718-64-0
2,3-dimethoxyphenylcarbamic acid ethyl ester

: 70837-64-8
6-methoxy-7-hydroxy-2,3-dihydroindole

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium hydroxide / ethanol; water / 3 h / 10 °C / Reflux

2.1: boron trichloride / 1,2-dichloro-ethane / 0 °C / Inert atmosphere

2.2: 3 h / Inert atmosphere; Reflux

3.1: sodium tetrahydroborate / 1,4-dioxane; water / 3 h / 0 - 90 °C

4.1: potassium carbonate / 1,4-dioxane / 1 h / 150 °C / Microwave irradiation

5.1: triethylamine / dichloromethane / 0.5 h / 0 - 20 °C

6.1: 5%-palladium/activated carbon; hydrogen; acetic acid / 16 h / 20 °C

With sodium tetrahydroborate; 5%-palladium/activated carbon; hydrogen; boron trichloride; potassium carbonate; acetic acid; triethylamine; potassium hydroxide; In 1,4-dioxane; ethanol; dichloromethane; water; 1,2-dichloro-ethane;
DOI:10.1021/jm400867d

Reference yield:

: 6299-67-8
2,3-dimethoxyaniline

: 70837-64-8
6-methoxy-7-hydroxy-2,3-dihydroindole

Guidance literature:: Multi-step reaction with 5 steps

1.1: boron trichloride / 1,2-dichloro-ethane / 0 °C / Inert atmosphere

1.2: 3 h / Inert atmosphere; Reflux

2.1: sodium tetrahydroborate / 1,4-dioxane; water / 3 h / 0 - 90 °C

3.1: potassium carbonate / 1,4-dioxane / 1 h / 150 °C / Microwave irradiation

4.1: triethylamine / dichloromethane / 0.5 h / 0 - 20 °C

5.1: 5%-palladium/activated carbon; hydrogen; acetic acid / 16 h / 20 °C

With sodium tetrahydroborate; 5%-palladium/activated carbon; hydrogen; boron trichloride; potassium carbonate; acetic acid; triethylamine; In 1,4-dioxane; dichloromethane; water; 1,2-dichloro-ethane;
DOI:10.1021/jm400867d