6299-67-8

Basic information

• Product Name: 2,3-DIMETHOXYANILINE
• Synonyms: Dimethoxyaniline;2,3-Dimethoxy-phenylamine;Nsc44873;2,3-Dimethoxyaniline ,98%;BenzenaMine, 2,3-diMethoxy-;(2,3-dimethoxyphenyl)amine hydrochloride
• CAS NO: 6299-67-8
• Molecular Formula: C₈H₁₁NO₂
• Molecular Weight: 153.17844
• Mol File: 6299-67-8.mol
• Article Data: 21

Chemical Properties

• Boiling Point: 93 °C / 1.4mmHg
• Appearance: /
• Density: 1,14 g/cm3
• Refractive Index: 1.5630-1.5650
• Storage Temp.: Refrigerator
• PKA: 4.12±0.10(Predicted)
• CAS DataBase Reference: 2,3-DIMETHOXYANILINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,3-DIMETHOXYANILINE(6299-67-8)
• EPA Substance Registry System: 2,3-DIMETHOXYANILINE(6299-67-8)

Safety Data

• Statements: 20/21/22-36/37/38-36/38
• Safety Statements: 26-36/37/39-51-20/21
• HazardClass: IRRITANT
• Hazardous Substances Data: 6299-67-8(Hazardous Substances Data)

Usage

Uses

2,3-Dimethoxyaniline can be used for composition of hair dye consisting of a monoaminobenzene and a metal catalyst.

Upstream product

• 182205-44-3 benzyl 2,3-dimethoxyphenylcarbamate 
• 343773-22-8 N-hydroxy-2,3-dimethoxybenzamide 
• 15969-08-1 6-methoxy-2-nitrophenol 
• 86-51-1 2,3-dimethyoxybenzaldehyde 
• 91-16-7 1,2-dimethoxybenzene 
• 7169-06-4 2,3-dimethoxybenzoyl chloride 
• 1521-38-6 2,3-dimethoxybenzoic acid 
• 56475-31-1 2.3-Dimethoxybenzoylazid 
• 101252-15-7 2,3-dichloro-5,6-dimethoxy-aniline 
• 116454-65-0 2,3-dimethoxytrifluoroacetanilide 
• 2785-95-7 3-lithio-1,2-dimethoxybenzene 
• 116668-84-9 3-nitroveratrole 
• 5701-87-1 3,4-dimethoxyanthranilic acid 
• 1521-39-7 2,3-dimethoxybenzamide 

Downstream Products

• 183436-40-0 (2-Amino-3,4-dimethoxy-phenyl)-methylsulfanyl-acetic acid 
• 365242-41-7 N-(2,3-dimethoxyphenyl)-3-oxobutanamide 
• 258532-75-1 2-chloro-N-(2,3-dimethoxyphenyl)acetamide 
• 908003-67-8 6-iodo-2,3-dimethoxyphenylamine 
• 436810-54-7 3-(2,3-dimethoxyphenylamino)propionic acid 
• 121639-09-6 N-(2,3-dimethoxyphenyl)acetamide 
• 326479-09-8 N-(2,3-dimethoxyphenyl)-3-(phenylsulfanyl)propionamide 

Relevant articles and documents

SYNTHETIC MYCOTOXIN ADSORBENTS AND METHODS OF MAKING AND UTILIZING THE SAME

The present invention relates generally to molecularly imprinted polymers (MIPs). In particular, the present invention relates to reusable, ecologically friendly MIPs that can be produced in relatively large quantities, methods of producing the same, and

One-pot synthesis of primary amines from carboxylic acids through rearrangement of in situ generated hydroxamic acid derivatives

A one-pot synthesis of primary amines from carboxylic acids through a Lossen rearrangement of hydroxamic acid derivatives, which were in situ generated by the reaction of carboxylic acids with O-trimethylsilylhydroxylamine (NH2OTMS) and carbonyl diimidazole (CDI, 1.5 equiv) in dimethyl sulfoxide at room temperature, has been achieved. This one-pot method could be applied to various carboxylic acids such as aromatic, heteroaromatic, aliphatic, and optically active substrates.

6-Methoxy-7-benzofuranoxy and 6-methoxy-7-indolyloxy analogues of 2-[2-(2,6-Dimethoxyphenoxy)ethyl]aminomethyl-1,4-benzodioxane (WB4101):1 Discovery of a potent and selective α1D-adrenoceptor antagonist

Previous results have shown that replacement of one of the two o-methoxy groups at the phenoxy residue of the potent, but not subtype-selective, α1-AR antagonist (S)-WB4101 [(S)-1] by phenyl, or by ortho,meta-fused cyclohexane, or especially by ortho,meta-fused benzene preferentially elicits α1D-AR antagonist affinity. Such observations inspired the design of four new analogues of 1 bearing, in lieu of the 2,6-dimethoxyphenoxy residue, a 6-methoxy-substituted 7-benzofuranoxy or 7-indolyloxy group or, alternatively, their corresponding 2,3-dihydro form. Of these new compounds, which maintain, rigidified, the characteristic ortho heterodisubstituted phenoxy substructure of 1, the S enantiomer of the dihydrobenzofuranoxy derivative exhibited the highest α1D-AR antagonist affinity (pA2 9.58) with significant α1D/ α1A and α1D/α1B selectivity. In addition, compared both to α1D-AR antagonists structurally related to 1 and to the well-known α1D-AR antagonist BMY7378, this derivative had modest 5-HT1A affinity and neutral α1-AR antagonist behavior.