1,3-DIMETHYL-1H-PYRAZOL-4-AMINE

Base Information

• Chemical Name: 1,3-DIMETHYL-1H-PYRAZOL-4-AMINE
• CAS No.: 64517-88-0
• Molecular Formula: C5H9N3
• Molecular Weight: 111.147
• Hs Code.: 2933199090
• Mol file: 64517-88-0.mol

Synonyms:1,3-Dimethyl-4-aminopyrazole;4-Amino-1,3-dimethyl-1H-pyrazole;4-Amino-1,3-dimethylpyrazole;1,3-Dimethyl-1H-pyrazol-4-amine;

Chemical Property of 1,3-DIMETHYL-1H-PYRAZOL-4-AMINE

Chemical Property:

• Boiling Point: 231.5 °C at 760 mmHg
• PKA: 4.18±0.10(Predicted)
• Flash Point: 93.8 °C
• PSA: 43.84000
• Density: 1.17 g/cm³
• LogP: 0.89190
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

98% ^*data from raw suppliers

4-Amino-1,3-dimethylpyrazole ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1,3-DIMETHYL-1H-PYRAZOL-4-AMINE

There total 5 articles about 1,3-DIMETHYL-1H-PYRAZOL-4-AMINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-methyl-4-nitro-1H-pyrazole (5334-39-4) + methyl iodide (74-88-4) → 1,3-dimethyl-1H-pyrazol-4-amine (64517-88-0) + 4-amino-1,5-dimethyl-1H-pyrazole (121983-36-6)

Guidance literature:

3-methyl-4-nitro-1H-pyrazole; methyl iodide; With hydrogen; sodium hydride; In tetrahydrofuran; mineral oil; at 0 - 27 ℃; for 4h;

With hydrogen; palladium(II) hydroxide; In ethanol; for 14h; Overall yield = 67 %; Overall yield = 3 g;

Reference yield:

5-methyl-4-nitro-1H-pyrazole + methyl iodide (74-88-4) → 1,3-dimethyl-1H-pyrazol-4-amine (64517-88-0) + 4-amino-1,5-dimethyl-1H-pyrazole (121983-36-6)

Guidance literature:

5-methyl-4-nitro-1H-pyrazole; methyl iodide; In acetone; at 60 ℃; for 20h;

With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃; for 6h;

Reference yield:

1,3-dimethyl-4-nitro-1H-pyrazole (3920-38-5) → 1,3-dimethyl-1H-pyrazol-4-amine (64517-88-0)

Guidance literature:

With hydrazine hydrate; Ra-Ni; In ethanol; Heating;

upstream raw materials:

1,3-dimethyl-4-nitro-1H-pyrazole

1,3-dimethyl-1H-pyrazole

3-methyl-4-nitro-1H-pyrazole

methyl iodide

Downstream raw materials:

C₂₄H₂₄N₄O₄

N-(1,3-dimethyl-1H-pyrazol-4-yl)-2-[2-methoxy-4-(7-methoxyquinolin-4-yloxy)phenyl]acetamide

Refernces

• 1、 -. "SUBSTITUTED PYRIMIDINE COMPOUNDS, COMPOSITIONS AND MEDICINAL APPLICATIONS THEREOF". Paragraph 000120. . Retrieved 2015/03/13.
• 2、 -. "HETEROCYCLYL PYRAZOLOPYRIMIDINE ANALOGUES AS JAK INHIBITORS". Page/Page column 121. . Retrieved 2011/05/06.