2-Methyl-4,5-diphenyl-1H-imidazole

Base Information

• Chemical Name: 2-Methyl-4,5-diphenyl-1H-imidazole
• CAS No.: 2818-82-8
• Molecular Formula: C16H14 N2
• Molecular Weight: 234.301
• European Community (EC) Number: 654-146-0
• NSC Number: 39454
• DSSTox Substance ID: DTXSID70284870
• Nikkaji Number: J1.299.388I
• Wikidata: Q82020033
• ChEMBL ID: CHEMBL225270
• Mol file: 2818-82-8.mol

Synonyms:2-Methyl-4,5-diphenyl-1H-imidazole;2818-82-8;SR-01000683130-2;2-methyl-4,5-diphenylimidazole;NSC39454;ChemDiv2_003613;Oprea1_435428;Oprea1_514794;MLS000526569;CHEMBL225270;cid_236696;SCHEMBL1068923;BDBM67469;DTXSID70284870;WBDSXISQIHMTGL-UHFFFAOYSA-N;HMS1379E05;HMS2155D07;HMS3314F02;CCG-16111;NSC-39454;STK004878;AKOS000546744;4,5-DIPHENYL-2-METHYLIMIDAZOLE;IDI1_002328;CL-57130;SMR000117043

Chemical Property of 2-Methyl-4,5-diphenyl-1H-imidazole

Chemical Property:

• Vapor Pressure: 1.31E-07mmHg at 25°C
• Boiling Point: 442.5°C at 760 mmHg
• Flash Point: 234.2°C
• Density: 1.127g/cm³
• XLogP3: 3.8
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 2
• Exact Mass: 234.115698455
• Heavy Atom Count: 18
• Complexity: 254

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=NC(=C(N1)C2=CC=CC=C2)C3=CC=CC=C3

Technology Process of 2-Methyl-4,5-diphenyl-1H-imidazole

There total 17 articles about 2-Methyl-4,5-diphenyl-1H-imidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

acetaldehyde (75-07-0,9002-91-9) + benzil (134-81-6) → 2-methyl-4,5-diphenyl-1H-imidazole (2818-82-8)

Guidance literature:

With C₉H₁₉N₂O₂⁽¹⁺⁾*C₂H₃O₂^(1-); ammonium acetate; water; at 60 ℃; for 0.1h; Sonication; Green chemistry;

DOI:10.1039/c8ra02755b

Reference yield: 91.0%

2-hydroxy-2-phenylacetophenone (119-53-9,579-44-2) + acetaldehyde (75-07-0,9002-91-9) → 2-methyl-4,5-diphenyl-1H-imidazole (2818-82-8)

Guidance literature:

With 1-hexyl-3-methyl-1H-imidazol-3-ium trifluoroacetate; ammonium acetate; In water; at 80 ℃; for 1h; Green chemistry;

DOI:10.1016/j.tetlet.2013.03.008

Reference yield: 76.0%

N-(2-oxo-1,2-diphenylethyl)acetamide (3893-31-0) → 2-methyl-4,5-diphenyl-1H-imidazole (2818-82-8)

Guidance literature:

With ammonium acetate; In acetic acid; for 1h; Heating;

upstream raw materials:

2-methyl-4,5-diphenyloxazole

2-acetoxy-2-phenylacetophenone

ammonium acetate

2-amino-1,2-diphenylethanone

Downstream raw materials:

1-ethyl-2-methyl-4,5-diphenyl-1H-imidazole

4-cyclohexyl-2-methyl-5-phenyl-1⁽³⁾H-imidazole

4,5-dicyclohexyl-2-methyl-1H-imidazole

2-methyl-4,5-diphenyl-imidazolidine