N-(2-Benzoylphenyl)-4-methylbenzenesulfonamide

Base Information

• Chemical Name: N-(2-Benzoylphenyl)-4-methylbenzenesulfonamide
• CAS No.: 1859-71-8
• Molecular Formula: C20H17 N O3 S
• Molecular Weight: 351.426
• NSC Number: 31415
• DSSTox Substance ID: DTXSID00940013
• Nikkaji Number: J2.072.747K
• Mol file: 1859-71-8.mol

Synonyms:N-(2-Benzoylphenyl)-4-methylbenzenesulfonamide;1859-71-8;NSC31415;2-tosylaminobenzophenone;2-(Tosylamino)benzophenone;Oprea1_730845;SCHEMBL27995;DTXSID00940013;NSC-31415;STK022260;2-(p-Toluenesulfonylamino)benzophenone;AKOS001658969;p-Tolylsulfonamide, N-(2'-benzoylphenyl)-;N-(2-Benzoylphenyl)-4-methylbenzenesulfonamide #;SR-01000480648;N-(2-Benzoylphenyl)-4-methylbenzene-1-sulfonamide;SR-01000480648-1;4-methyl-N-[2-(phenylcarbonyl)phenyl]benzenesulfonamide

Chemical Property of N-(2-Benzoylphenyl)-4-methylbenzenesulfonamide

Chemical Property:

• Vapor Pressure: 7.45E-12mmHg at 25°C
• Refractive Index: 1.637
• Boiling Point: 543°C at 760 mmHg
• Flash Point: 282.2°C
• Density: 1.287g/cm³
• XLogP3: 4.7
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 5
• Exact Mass: 351.09291458
• Heavy Atom Count: 25
• Complexity: 540

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC=C(C=C1)S(=O)(=O)NC2=CC=CC=C2C(=O)C3=CC=CC=C3

Technology Process of N-(2-Benzoylphenyl)-4-methylbenzenesulfonamide

There total 16 articles about N-(2-Benzoylphenyl)-4-methylbenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

p-toluenesulfonyl chloride (98-59-9) + (2-aminophenyl)(phenyl)methanone (2835-77-0) → 2-(tosylamino)benzophenone (1859-71-8)

Guidance literature:

With pyridine; In dichloromethane; at 20 ℃;

DOI:10.1055/s-2006-926398

Reference yield: 84.0%

N-(2-Formyl-phenyl)-4-methyl-benzenesulfonamide (6590-65-4) + mesityl(phenyl)iodonium trifluoromethanesulfonate → 2-(tosylamino)benzophenone (1859-71-8)

Guidance literature:

With dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; cesium acetate; silver(I) triflimide; In dichloromethane; at 80 ℃; for 20h; Inert atmosphere; Sealed tube;

DOI:10.1039/c6ob00825a

Reference yield: 84.0%

iodobenzene (591-50-4) + N-(2-Formyl-phenyl)-4-methyl-benzenesulfonamide (6590-65-4) → 2-(tosylamino)benzophenone (1859-71-8)

Guidance literature:

With dicarbonylacetylacetonato rhodium (I); sodium hydrogencarbonate; In N,N-dimethyl-formamide; at 100 ℃; for 2h; Schlenk technique; Inert atmosphere;

DOI:10.1002/ejoc.201700881

upstream raw materials:

2-(toluene-4-sulfonylamino)-benzoic acid

p-toluenesulfonyl chloride

(2-aminophenyl)(phenyl)methanone

2-(Toluene-4-sulfonylamino)-benzoyl chloride

Downstream raw materials:

toluene-4-sulfonic acid-(2-benzoyl-N-methyl-anilide)

(2-aminophenyl)(phenyl)methanone

N-(2-benzoyl-phenyl)-4-methyl-N-octyl-benzenesulfonamide

-benzophenon