methyl 5-amino-2-hydroxybenzoate hydrochloride (1:1)

Base Information

• Chemical Name: methyl 5-amino-2-hydroxybenzoate hydrochloride (1:1)
• CAS No.: 110065-66-2
• Molecular Formula: C₈H₉NO₃*ClH
• Molecular Weight: 203.625
• Mol file: 110065-66-2.mol

Synonyms:Benzoicacid, 5-amino-2-hydroxy-, methyl ester, hydrochloride (9CI)

Chemical Property of methyl 5-amino-2-hydroxybenzoate hydrochloride (1:1)

Chemical Property:

• Vapor Pressure: 0.000184mmHg at 25°C
• Boiling Point: 319.2°C at 760 mmHg
• Flash Point: 146.8°C

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of methyl 5-amino-2-hydroxybenzoate hydrochloride (1:1)

There total 3 articles about methyl 5-amino-2-hydroxybenzoate hydrochloride (1:1) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

methanol (67-56-1) + 5-Aminosalicylic Acid (89-57-6) → methyl 5-aminosalicylate hydrochloride (110065-66-2)

Guidance literature:

methanol; With thionyl chloride; Cooling;

5-Aminosalicylic Acid; for 1.5h; Reflux;

DOI:10.1002/cmdc.202000786

Reference yield:

5-Aminosalicylic Acid (89-57-6) → methyl 5-aminosalicylate hydrochloride (110065-66-2)

Guidance literature:

Multi-step reaction with 2 steps

1: SOCl₂

With thionyl chloride;

DOI:10.1021/jm00077a014

Reference yield:

methanol (67-56-1) + 5-Amino-2-hydroxy-benzoyl chloride → methyl 5-aminosalicylate hydrochloride (110065-66-2)

Guidance literature:

DOI:10.1021/jm00077a014

upstream raw materials:

methanol

5-Aminosalicylic Acid