Dibenzo[b,f]thiepin

Base Information

• Chemical Name: Dibenzo[b,f]thiepin
• CAS No.: 257-13-6
• Molecular Formula: C14H10 S
• Molecular Weight: 210.29
• Hs Code.: 2934999090
• Mol file: 257-13-6.mol

Synonyms:NSC 102282

Chemical Property of Dibenzo[b,f]thiepin

Chemical Property:

• Vapor Pressure: 0.000135mmHg at 25°C
• Boiling Point: 344°C at 760 mmHg
• Flash Point: 159.1°C
• PSA: 25.30000
• Density: 1.19g/cm³
• LogP: 4.32160

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Dibenzo[b,f]thiepin

There total 4 articles about Dibenzo[b,f]thiepin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

10-chloro-10,11-dihydro-dibenzo[b,f]thiepine (1725-32-2) → Di-<10,11-dihydro-dibenzothiepinyl-(10)>-ether (16661-24-8) + dibenzo[b,f]thiepine (257-13-6)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; for 12h; Heating;

DOI:10.1135/cccc19831187

Reference yield: 44.0%

(E)-2,2'-dichlorostilbene (25144-38-1) → dibenzo[b,f]thiepine (257-13-6) + 2-chloro-2'-mercaptostilbene (1254175-17-1) + 2-(2-chlorophenyl)-2,3-dihydrobenzo[b]thiophene (1254175-16-0)

Guidance literature:

With sodium sulphide nonahydrate; In 1-methyl-pyrrolidin-2-one; at 180 ℃; for 16h; Inert atmosphere;

DOI:10.1016/j.tetlet.2010.07.152

Reference yield: 30.0%

(E)-2,2'-dibromostilbene (56667-12-0) → benzthieno[3,2-b]benzothiophene (248-70-4) + 2-phenylbenzo[b]thiophene (1207-95-0) + dibenzo[b,f]thiepine (257-13-6)

Guidance literature:

With sodium sulphide nonahydrate; sulfur; In 1-methyl-pyrrolidin-2-one; at 180 ℃; for 16h; Inert atmosphere;

DOI:10.1016/j.tetlet.2010.07.152

upstream raw materials:

10-chloro-10,11-dihydro-dibenzo[b,f]thiepine

(E)-2,2'-dichlorostilbene

(E)-2,2'-dibromostilbene

Downstream raw materials:

dibenzo[b,f]thiepin-10(11H)-one

Refernces

9 Chloro 10 (4 methylpiperazino) 10,11 dihydrodibenzo[b,f] thiepin and some related synthetic experiments

10.1135/cccc19740333

The research focused on the synthesis of 9-chloro-10-(4-methylpiperazino)-10,11-dihydrodibenzo[b,f]thiepin (I), a compound belonging to the neurotropic and psychotropic agents class. The study aimed to understand the impact of molecular substitution on the activity of the compound, particularly exploring the effects of chlorine substitution at different positions on the perathiepin molecule. The researchers concluded that substitution at the 9th position of the perathiepin molecule negatively affects the neuroleptic activity, rendering compound I practically inactive as a central depressant and cataleptic agent. Key chemicals used in the synthesis process included 1-chloro-9-methylenethioxanthene (IX), thallic nitrate, methanol, 1-chlorothioxanthone (VI), and various derivatives of dibenzo[b,f]thiepin. The synthesis involved multiple steps, such as oxidation, hydrolysis, and substitution reactions, and utilized various reagents like methylmagnesium iodide, hydrochloric acid, and sulfuric acid, among others.

Potential psychotropic and anthistamine agents: 1- and 3-alkyl-9-(3-dimethylaminopropylidene)- thioxanthenes and 3-alkyl-11-piperazino-10,11-dihydrodibenzo[b,f]thiepins

10.1135/cccc19823134

The research explores the synthesis and pharmacological properties of various thioxanthene and dibenzo[b,f]thiepin derivatives. The study involves the use of chemicals such as 3-methylthiophenol, 3-ethylthiophenol, 2-iodobenzoic acid, (2-iodophenyl)acetic acid, potassium hydroxide, copper, sulfuric acid, polyphosphoric acid, 3-dimethylaminopropylmagnesium chloride, and various piperazine derivatives. These chemicals are used in a series of reactions to produce compounds with potential antihistamine and psychotropic activities. The synthesized compounds are tested for their pharmacological effects, including antihistamine activity, central depressant effects, cataleptic activity, and antireserpine activity. The research aims to investigate the impact of substituents in unusual positions on the pharmacological profiles of these compounds, with potential applications in treating conditions like gastric hyperacidity, ulcers, and central nervous system disorders.