2-(4-METHOXYPHENYL)ACETOHYDRAZIDE

Base Information

• Chemical Name: 2-(4-METHOXYPHENYL)ACETOHYDRAZIDE
• CAS No.: 57676-49-0
• Molecular Formula: C9H12N2O2
• Molecular Weight: 180.206
• Hs Code.: 2928000090
• Mol file: 57676-49-0.mol

Synonyms:Aceticacid, (p-methoxyphenyl)-, hydrazide (6CI);(4-Methoxyphenyl)acetic acidhydrazide;4-Methoxyphenylacetic hydrazide;(4-Methoxyphenyl)acetic acid hydrazide;

Chemical Property of 2-(4-METHOXYPHENYL)ACETOHYDRAZIDE

Chemical Property:

• Vapor Pressure: 1.04E-06mmHg at 25°C
• Refractive Index: 1.549
• Boiling Point: 403.1 °C at 760 mmHg
• Flash Point: 197.6 °C
• PSA: 64.35000
• Density: 1.156g/cm³
• LogP: 1.31880
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-(4-Methoxyphenyl)acetohydrazide ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi,Xn
• Statements: 22

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(4-METHOXYPHENYL)ACETOHYDRAZIDE

There total 6 articles about 2-(4-METHOXYPHENYL)ACETOHYDRAZIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

4-methoxy-phenyl acetic acid methyl ester (23786-14-3) → 2-(4-methoxyphenyl)acetic acid hydrazide (57676-49-0)

Guidance literature:

With hydrazine; for 16h; Heating / reflux;

Reference yield: 86.0%

4-methoxyphenyl-acetic chloride (4693-91-8) → 2-(4-methoxyphenyl)acetic acid hydrazide (57676-49-0)

Guidance literature:

With hydrazine hydrate; triethylamine; In acetonitrile; for 3h; Reflux;

DOI:10.2174/1573406410666140327142912

Reference yield: 75.0%

4-Methoxyphenylacetic acid (104-01-8) → 2-(4-methoxyphenyl)acetic acid hydrazide (57676-49-0)

Guidance literature:

4-Methoxyphenylacetic acid; With nicotinic acid; sulfuric acid; In methanol; for 6h; Reflux;

With hydrazine hydrate; In methanol; at 65 ℃; for 4h;

DOI:10.1080/07391102.2021.1942212

upstream raw materials:

4-methoxy-phenyl acetic acid methyl ester

4-methoxyphenyl-acetic chloride

ethyl p-methoxyphenylacetate

4-Methoxyphenylacetic acid

Downstream raw materials:

5,5'-bis-(4-methoxy-benzyl)-2,3,2',3'-tetrahydro-3,3'-(2-oxa-propane-1,3-diyl)-bis-[1,3,4]oxadiazole

5-(4-Methoxy-benzyl)-4-(4-methoxy-phenyl)-2,4-dihydro-[1,2,4]triazol-3-one

4-(4-Ethoxy-phenyl)-5-(4-methoxy-benzyl)-2,4-dihydro-[1,2,4]triazol-3-one

4-(4-Isopropoxy-phenyl)-5-(4-methoxy-benzyl)-2,4-dihydro-[1,2,4]triazol-3-one

Refernces

• 1、 Crider, A. Michael,Farr, Susan A.,Frare, Rafael,Hospital, Audrey,Kontoyianni, Maria,Kukielski, Stephen G.,Minaeian, Mahsa,Mobayen, Shirin,Neumann, William L.,Niehoff, Michael L.,Sandoval, Karin E.,Slater, Olivia,Srabony, Khush N.,Witt, Ken A.. "Synthesis and structure-activity relationships of 3,4,5-trisubstituted-1,2,4-triazoles: High affinity and selective somatostatin receptor-4 agonists for Alzheimer's disease treatment". . p. 1352 - 1365. Retrieved 2021/11/09.
• 2、 -. "Novel 1,3,4-oxadiazole Compound and Pharmaceutical Composition For Lowering Blood Glucose Comprising The Same". Paragraph 0043; 0050; 0051; 0054. . Retrieved 2019/10/22.