3-hydroxy-4-nitrocinnamic acid

Base Information

• Chemical Name: 3-hydroxy-4-nitrocinnamic acid
• CAS No.: 182500-01-2
• Molecular Formula: C₉H₇NO₅
• Molecular Weight: 209.158
• Mol file: 182500-01-2.mol

Synonyms:

Chemical Property of 3-hydroxy-4-nitrocinnamic acid

Chemical Property:

Purity/Quality:

(E)-3-(3-hydroxy-4-nitrophenyl)acrylic acid 97 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-hydroxy-4-nitrocinnamic acid

There total 6 articles about 3-hydroxy-4-nitrocinnamic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 26.0%

3-hydroxy-trans-cinnamic acid (14755-02-3,588-30-7) → 3-hydroxy-4-nitrocinnamic acid (90729-86-5,182500-01-2)

Guidance literature:

With sodium nitrate; sulfuric acid; sodium nitrite; In dichloromethane;

Reference yield:

malonic acid (141-82-2) + 4-hydroxy-3-nitrobenzaldehyde (3011-34-5) → 3-hydroxy-4-nitrocinnamic acid (90729-86-5,182500-01-2)

Guidance literature:

piperidine; In toluene; Heating / reflux;

Reference yield:

3-hydroxy-trans-cinnamic acid (14755-02-3,588-30-7) → 3-hydroxy-4-nitrocinnamic acid (90729-86-5,182500-01-2) + 2-Nitro-5-hydroxycinnamic acid (142010-16-0)

Guidance literature:

With cerium(IV) ammonium nitrate supported on silica; magnesium sulfate; In dichloromethane; at 20 ℃; for 0.166667h;

DOI:10.1081/SCC-200030569

upstream raw materials:

malonic acid

5-formyl-2-nitrophenol

3-hydroxycinnamic acid

nitric acid

Downstream raw materials:

(E)-N-(3-chlorophenyl)-3-(3-hydroxy-4-nitrophenyl)-prop-2-enamide

(E)-N-(3-chlorophenyl)-3-(4-amino-3-hydroxyphenyl)-prop-2-enamide

Refernces

• 1、 -. "Bicyclic cyclohexylamines and their use as nmda receptor antagonists". Page 10-11. . Retrieved 2010/02/06.
• 2、 -. "IL-8 RECEPTOR ANTAGONISTS". . . Retrieved 2008/06/13.