(R)-tertbutyl 4-((R)-1-(5-(4-(bis(4-methoxybenzyl)amino)-6-methyl-1,3,5-triazin-2-yl)-6-((5-fluoro-6-methoxypyridin-3-yl)amino)pyridin-3-yl)-ethyl)-3-methylpiperazine-1-carboxylate

Base Information

Chemical Name:(R)-tertbutyl 4-((R)-1-(5-(4-(bis(4-methoxybenzyl)amino)-6-methyl-1,3,5-triazin-2-yl)-6-((5-fluoro-6-methoxypyridin-3-yl)amino)pyridin-3-yl)-ethyl)-3-methylpiperazine-1-carboxylate
CAS No.:1253578-43-6
Molecular Formula:C₄₃H₅₂FN₉O₅
Molecular Weight:793.942
Hs Code.:

(R)-tertbutyl 4-((R)-1-(5-(4-(bis(4-methoxybenzyl)amino)-6-methyl-1,3,5-triazin-2-yl)-6-((5-fluoro-6-methoxypyridin-3-yl)amino)pyridin-3-yl)-ethyl)-3-methylpiperazine-1-carboxylate

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Chemical Property of (R)-tertbutyl 4-((R)-1-(5-(4-(bis(4-methoxybenzyl)amino)-6-methyl-1,3,5-triazin-2-yl)-6-((5-fluoro-6-methoxypyridin-3-yl)amino)pyridin-3-yl)-ethyl)-3-methylpiperazine-1-carboxylate

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Technology Process of (R)-tertbutyl 4-((R)-1-(5-(4-(bis(4-methoxybenzyl)amino)-6-methyl-1,3,5-triazin-2-yl)-6-((5-fluoro-6-methoxypyridin-3-yl)amino)pyridin-3-yl)-ethyl)-3-methylpiperazine-1-carboxylate

There total 4 articles about (R)-tertbutyl 4-((R)-1-(5-(4-(bis(4-methoxybenzyl)amino)-6-methyl-1,3,5-triazin-2-yl)-6-((5-fluoro-6-methoxypyridin-3-yl)amino)pyridin-3-yl)-ethyl)-3-methylpiperazine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 677728-92-6
2-fluoro-5-formylpyridine

: 1253578-43-6
(R)-tertbutyl 4-((R)-1-(5-(4-(bis(4-methoxybenzyl)amino)-6-methyl-1,3,5-triazin-2-yl)-6-((5-fluoro-6-methoxypyridin-3-yl)amino)pyridin-3-yl)-ethyl)-3-methylpiperazine-1-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1.1: tetrahydrofuran; diethyl ether / 0.33 h / -6 - -5 °C

2.1: sulfurous dibromide / dichloromethane / 3 h / 25 °C

3.1: potassium carbonate; potassium iodide / acetonitrile / 16 h / 70 °C

4.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 °C

4.2: 1 h / -78 °C

5.1: potassium acetate; bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II) / water; 1,4-dioxane / 0.33 h / 120 °C / Microwave irradiation

6.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -40 °C

With sulfurous dibromide; n-butyllithium; bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II); potassium acetate; potassium carbonate; potassium iodide; lithium hexamethyldisilazane; In tetrahydrofuran; 1,4-dioxane; diethyl ether; hexane; dichloromethane; water; acetonitrile; 5.1: |Suzuki-Miyaura Coupling;
DOI:10.1021/jm300846z

Reference yield:

: 1034467-37-2
1-(6-fluoropyridin-3-yl)ethan-1-ol

: 1253578-43-6
(R)-tertbutyl 4-((R)-1-(5-(4-(bis(4-methoxybenzyl)amino)-6-methyl-1,3,5-triazin-2-yl)-6-((5-fluoro-6-methoxypyridin-3-yl)amino)pyridin-3-yl)-ethyl)-3-methylpiperazine-1-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: sulfurous dibromide / dichloromethane / 3 h / 25 °C

2.1: potassium carbonate; potassium iodide / acetonitrile / 16 h / 70 °C

3.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 °C

3.2: 1 h / -78 °C

4.1: potassium acetate; bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II) / water; 1,4-dioxane / 0.33 h / 120 °C / Microwave irradiation

5.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -40 °C

With sulfurous dibromide; n-butyllithium; bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II); potassium acetate; potassium carbonate; potassium iodide; lithium hexamethyldisilazane; In tetrahydrofuran; 1,4-dioxane; hexane; dichloromethane; water; acetonitrile; 4.1: |Suzuki-Miyaura Coupling;
DOI:10.1021/jm300846z

Reference yield:

: 1253578-40-3
(3R)-tert-butyl 4-(1-(6-fluoropyridin-3-yl)ethyl)-3-methylpiperazine-1-carboxylate

: 1253578-43-6
(R)-tertbutyl 4-((R)-1-(5-(4-(bis(4-methoxybenzyl)amino)-6-methyl-1,3,5-triazin-2-yl)-6-((5-fluoro-6-methoxypyridin-3-yl)amino)pyridin-3-yl)-ethyl)-3-methylpiperazine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 °C

1.2: 1 h / -78 °C

2.1: potassium acetate; bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II) / water; 1,4-dioxane / 0.33 h / 120 °C / Microwave irradiation

3.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -40 °C

With n-butyllithium; bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II); potassium acetate; lithium hexamethyldisilazane; In tetrahydrofuran; 1,4-dioxane; hexane; water; 2.1: |Suzuki-Miyaura Coupling;
DOI:10.1021/jm300846z