4-(2-((5-fluoro-6-methoxypyridin-3-yl)amino)-5-((R)-1-((R)-2-methyl-4-(methylsulfonyl)piperazin-1-yl)ethyl)pyridin-3-yl)-N,N-bis-(4-methoxybenzyl)-6-methyl-1,3,5-triazin-2-amine

Base Information

Chemical Name:4-(2-((5-fluoro-6-methoxypyridin-3-yl)amino)-5-((R)-1-((R)-2-methyl-4-(methylsulfonyl)piperazin-1-yl)ethyl)pyridin-3-yl)-N,N-bis-(4-methoxybenzyl)-6-methyl-1,3,5-triazin-2-amine
CAS No.:1253578-45-8
Molecular Formula:C₃₉H₄₆FN₉O₅S
Molecular Weight:771.916
Hs Code.:

4-(2-((5-fluoro-6-methoxypyridin-3-yl)amino)-5-((R)-1-((R)-2-methyl-4-(methylsulfonyl)piperazin-1-yl)ethyl)pyridin-3-yl)-N,N-bis-(4-methoxybenzyl)-6-methyl-1,3,5-triazin-2-amine

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Chemical Property of 4-(2-((5-fluoro-6-methoxypyridin-3-yl)amino)-5-((R)-1-((R)-2-methyl-4-(methylsulfonyl)piperazin-1-yl)ethyl)pyridin-3-yl)-N,N-bis-(4-methoxybenzyl)-6-methyl-1,3,5-triazin-2-amine

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Technology Process of 4-(2-((5-fluoro-6-methoxypyridin-3-yl)amino)-5-((R)-1-((R)-2-methyl-4-(methylsulfonyl)piperazin-1-yl)ethyl)pyridin-3-yl)-N,N-bis-(4-methoxybenzyl)-6-methyl-1,3,5-triazin-2-amine

There total 7 articles about 4-(2-((5-fluoro-6-methoxypyridin-3-yl)amino)-5-((R)-1-((R)-2-methyl-4-(methylsulfonyl)piperazin-1-yl)ethyl)pyridin-3-yl)-N,N-bis-(4-methoxybenzyl)-6-methyl-1,3,5-triazin-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₃₈H₄₄FN₉O₃

: 124-63-0
methanesulfonyl chloride

: 1253578-45-8
4-(2-((5-fluoro-6-methoxypyridin-3-yl)amino)-5-((R)-1-((R)-2-methyl-4-(methylsulfonyl)piperazin-1-yl)ethyl)pyridin-3-yl)-N,N-bis-(4-methoxybenzyl)-6-methyl-1,3,5-triazin-2-amine

Guidance literature:: With triethylamine; In dichloromethane; at -50 ℃; for 0.5h;
DOI:10.1021/jm300846z

Reference yield:

: 677728-92-6
2-fluoro-5-formylpyridine

: 1253578-45-8
4-(2-((5-fluoro-6-methoxypyridin-3-yl)amino)-5-((R)-1-((R)-2-methyl-4-(methylsulfonyl)piperazin-1-yl)ethyl)pyridin-3-yl)-N,N-bis-(4-methoxybenzyl)-6-methyl-1,3,5-triazin-2-amine

Guidance literature:: Multi-step reaction with 8 steps

1.1: tetrahydrofuran; diethyl ether / 0.33 h / -6 - -5 °C

2.1: sulfurous dibromide / dichloromethane / 3 h / 25 °C

3.1: potassium carbonate; potassium iodide / acetonitrile / 16 h / 70 °C

4.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 °C

4.2: 1 h / -78 °C

5.1: potassium acetate; bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II) / water; 1,4-dioxane / 0.33 h / 120 °C / Microwave irradiation

6.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -40 °C

7.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

8.1: triethylamine / dichloromethane / 0.5 h / -50 °C

With sulfurous dibromide; n-butyllithium; bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II); potassium acetate; potassium carbonate; triethylamine; trifluoroacetic acid; potassium iodide; lithium hexamethyldisilazane; In tetrahydrofuran; 1,4-dioxane; diethyl ether; hexane; dichloromethane; water; acetonitrile; 5.1: |Suzuki-Miyaura Coupling;
DOI:10.1021/jm300846z

Reference yield:

: 1034467-37-2
1-(6-fluoropyridin-3-yl)ethan-1-ol

: 1253578-45-8
4-(2-((5-fluoro-6-methoxypyridin-3-yl)amino)-5-((R)-1-((R)-2-methyl-4-(methylsulfonyl)piperazin-1-yl)ethyl)pyridin-3-yl)-N,N-bis-(4-methoxybenzyl)-6-methyl-1,3,5-triazin-2-amine

Guidance literature:: Multi-step reaction with 7 steps

1.1: sulfurous dibromide / dichloromethane / 3 h / 25 °C

2.1: potassium carbonate; potassium iodide / acetonitrile / 16 h / 70 °C

3.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 °C

3.2: 1 h / -78 °C

4.1: potassium acetate; bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II) / water; 1,4-dioxane / 0.33 h / 120 °C / Microwave irradiation

5.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -40 °C

6.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

7.1: triethylamine / dichloromethane / 0.5 h / -50 °C

With sulfurous dibromide; n-butyllithium; bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II); potassium acetate; potassium carbonate; triethylamine; trifluoroacetic acid; potassium iodide; lithium hexamethyldisilazane; In tetrahydrofuran; 1,4-dioxane; hexane; dichloromethane; water; acetonitrile; 4.1: |Suzuki-Miyaura Coupling;
DOI:10.1021/jm300846z