C₂₇H₂₈FNO₆S

Base Information

• Chemical Name: C₂₇H₂₈FNO₆S
• CAS No.: 1356111-28-8
• Molecular Formula: C₂₇H₂₈FNO₆S
• Molecular Weight: 513.587
• Mol file: 1356111-28-8.mol

Synonyms:

Chemical Property of C₂₇H₂₈FNO₆S

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₇H₂₈FNO₆S

There total 10 articles about C₂₇H₂₈FNO₆S which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl 3-bromo-2-methoxy-6-methylbenzoate → C27H28FNO6S (1356111-28-8) + C27H28FNO6S (1356111-26-6)

Guidance literature:

Multi-step reaction with 9 steps

1.1: 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione / 2,2'-azobis(isobutyronitrile) / 1,2-dichloro-ethane / 0.67 h / 90 °C

2.1: potassium carbonate / tetrahydrofuran / 1 h / Reflux

2.2: 2 h / 20 - 80 °C

3.1: cesium fluoride / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran / Inert atmosphere; Reflux

4.1: aluminum (III) chloride; N,N-dimethyl-aniline / dichloromethane / 2 h / 0 - 20 °C

5.1: caesium carbonate; tri tert-butylphosphoniumtetrafluoroborate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane; water / 1 h / 65 °C / Inert atmosphere

6.1: sodium tetrahydroborate; methanol / tetrahydrofuran / 0.17 h / 10 - 20 °C

7.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 0.75 h / 10 - 20 °C

8.1: water; lithium hydroxide monohydrate / 1,4-dioxane / 3 h / 80 °C

9.1: isopropyl alcohol; n-heptane / Resolution of racemate

With methanol; aluminum (III) chloride; sodium tetrahydroborate; 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; lithium hydroxide monohydrate; di-isopropyl azodicarboxylate; water; potassium carbonate; caesium carbonate; N,N-dimethyl-aniline; triphenylphosphine; cesium fluoride; tri tert-butylphosphoniumtetrafluoroborate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 2,2'-azobis(isobutyronitrile); In tetrahydrofuran; 1,4-dioxane; n-heptane; dichloromethane; water; 1,2-dichloro-ethane; isopropyl alcohol;

Reference yield:

methyl 3-bromo-2-hydroxy-6-methylbenzoate (1286179-99-4) → C27H28FNO6S (1356111-28-8) + C27H28FNO6S (1356111-26-6)

Guidance literature:

Multi-step reaction with 10 steps

1.1: potassium carbonate / acetone / 2.5 h / Reflux

2.1: 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione / 2,2'-azobis(isobutyronitrile) / 1,2-dichloro-ethane / 0.67 h / 90 °C

3.1: potassium carbonate / tetrahydrofuran / 1 h / Reflux

3.2: 2 h / 20 - 80 °C

4.1: cesium fluoride / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran / Inert atmosphere; Reflux

5.1: aluminum (III) chloride; N,N-dimethyl-aniline / dichloromethane / 2 h / 0 - 20 °C

6.1: caesium carbonate; tri tert-butylphosphoniumtetrafluoroborate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane; water / 1 h / 65 °C / Inert atmosphere

7.1: sodium tetrahydroborate; methanol / tetrahydrofuran / 0.17 h / 10 - 20 °C

8.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 0.75 h / 10 - 20 °C

9.1: water; lithium hydroxide monohydrate / 1,4-dioxane / 3 h / 80 °C

10.1: isopropyl alcohol; n-heptane / Resolution of racemate

With methanol; aluminum (III) chloride; sodium tetrahydroborate; 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; lithium hydroxide monohydrate; di-isopropyl azodicarboxylate; water; potassium carbonate; caesium carbonate; N,N-dimethyl-aniline; triphenylphosphine; cesium fluoride; tri tert-butylphosphoniumtetrafluoroborate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 2,2'-azobis(isobutyronitrile); In tetrahydrofuran; 1,4-dioxane; n-heptane; dichloromethane; water; 1,2-dichloro-ethane; isopropyl alcohol; acetone;

Reference yield:

(Z)-methyl 3-bromo-6-((2-(3-(diethylamino)prop-1-enyl)-4-fluorobenzenesulfonyl)methyl)-2-methoxybenzoate (1286180-98-0) → C27H28FNO6S (1356111-28-8) + C27H28FNO6S (1356111-26-6)

Guidance literature:

Multi-step reaction with 6 steps

1: aluminum (III) chloride; N,N-dimethyl-aniline / dichloromethane / 2 h / 0 - 20 °C

2: caesium carbonate; tri tert-butylphosphoniumtetrafluoroborate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane; water / 1 h / 65 °C / Inert atmosphere

3: sodium tetrahydroborate; methanol / tetrahydrofuran / 0.17 h / 10 - 20 °C

4: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 0.75 h / 10 - 20 °C

5: water; lithium hydroxide monohydrate / 1,4-dioxane / 3 h / 80 °C

6: isopropyl alcohol; n-heptane / Resolution of racemate

With methanol; aluminum (III) chloride; sodium tetrahydroborate; lithium hydroxide monohydrate; di-isopropyl azodicarboxylate; water; caesium carbonate; N,N-dimethyl-aniline; triphenylphosphine; tri tert-butylphosphoniumtetrafluoroborate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; n-heptane; dichloromethane; water; isopropyl alcohol;

upstream raw materials:

methyl 3-bromo-2-hydroxy-6-methylbenzoate

(Z)-methyl 3-bromo-6-((2-(3-(diethylamino)prop-1-enyl)-4-fluorobenzenesulfonyl)methyl)-2-methoxybenzoate

methyl 3-bromo-6-(2-bromo-4-fluorobenzenesulphonylmethyl)-2-methoxybenzoate

(Z)-methyl 3-bromo-6-((2-(3-(diethylamino)prop-1-enyl)-4-fluorobenzenesulfonyl)methyl)-2-hydroxybenzoate