(R)-tert-Butyl 2-(2-methoxy-2-oxoethyl)pyrrolidine-1-carboxylate

Base Information

• Chemical Name: (R)-tert-Butyl 2-(2-methoxy-2-oxoethyl)pyrrolidine-1-carboxylate
• CAS No.: 132482-05-4
• Molecular Formula: C12H21 N O4
• Molecular Weight: 243.303
• European Community (EC) Number: 961-069-9
• Nikkaji Number: J2.117.285E
• Mol file: 132482-05-4.mol

Synonyms:132482-05-4;(R)-tert-Butyl 2-(2-methoxy-2-oxoethyl)pyrrolidine-1-carboxylate;2-Pyrrolidineacetic acid, 1-[(1,1-dimethylethoxy)carbonyl]-, methyl ester, (2r)-;TERT-BUTYL (2R)-2-(2-METHOXY-2-OXOETHYL)PYRROLIDINE-1-CARBOXYLATE;SCHEMBL20410;LZYBAKVGAMQFLJ-SECBINFHSA-N;MFCD12912364;AKOS015909999;DS-7425;EN300-7183350;A806441;(R)-tert-Butyl2-(2-methoxy-2-oxoethyl)pyrrolidine-1-carboxylate;tert-butyl (R)-2-(2-methoxy-2-oxoethyl)pyrrolidine-1-carboxylate;(R)-1-(tert-Butyloxycarbonyl)pyrrolidin-2-yl-acetic acid methyl ester

Chemical Property of (R)-tert-Butyl 2-(2-methoxy-2-oxoethyl)pyrrolidine-1-carboxylate

Chemical Property:

• Vapor Pressure: 0.548mmHg at 25°C
• Boiling Point: 190.215oC at 760 mmHg
• Flash Point: 68.84oC
• PSA: 38.33000
• Density: 1.006g/cm3
• LogP: 0.63030
• Storage Temp.: 2-8°C
• XLogP3: 1.5
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 5
• Exact Mass: 243.14705815
• Heavy Atom Count: 17
• Complexity: 295

Purity/Quality:

97% ^*data from raw suppliers

(R)-tert-Butyl2-(2-methoxy-2-oxoethyl)pyrrolidine-1-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)(C)OC(=O)N1CCCC1CC(=O)OC
• Isomeric SMILES: CC(C)(C)OC(=O)N1CCC[C@@H]1CC(=O)OC

Technology Process of (R)-tert-Butyl 2-(2-methoxy-2-oxoethyl)pyrrolidine-1-carboxylate

There total 26 articles about (R)-tert-Butyl 2-(2-methoxy-2-oxoethyl)pyrrolidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

methanol (67-56-1) + tert-butyl (S)-2-(diazoacetyl)pyrrolidine-1-carboxylate (101130-03-4) → (2S)-tert-Butyl 2-(2-methoxy-2-oxoethyl)pyrrolidine-2-carboxylate (88790-37-8,132482-05-4,813433-68-0)

Guidance literature:

With silver benzoate; triethylamine; at -25 - 20 ℃; for 3h;

DOI:10.1039/a906969k

Reference yield: 96.7%

2-(R)-carboxymethyl-pyrrolidine-1-carboxylic acid tert-butyl ester (101555-60-6) + diazomethyl-trimethyl-silane (18107-18-1) → methyl (R)-2-[N(1')-(tert-butoxycarbonyl)pyrrolidin-2'-yl]ethanoate (132482-05-4,813433-68-0)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In methanol; acetonitrile; at 0 - 20 ℃; for 3h; Inert atmosphere;

Reference yield: 96.0%

(S)-pyrrolidin-2-ylacetic acid methyl ester hydrochloride (259868-83-2) + di-tert-butyl dicarbonate (24424-99-5) → (2S)-tert-Butyl 2-(2-methoxy-2-oxoethyl)pyrrolidine-2-carboxylate (88790-37-8,132482-05-4,813433-68-0)

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 20 ℃;

DOI:10.1002/chir.21017

upstream raw materials:

diazomethane

tert-butyldicarbonate

L-proline

methanol

Downstream raw materials:

C₂₉H₄₁NO₃

(S)-1,1-bis(4-propylphenyl)-2-(pyrrolidin-2-yl)ethanol

C₃₃H₄₉NO₃

(S)-1,1-bis(4-pentylphenyl)-2-(pyrrolidin-2-yl)ethanol