8-Methyl-1-naphthalenemethanol

Base Information

• Chemical Name: 8-Methyl-1-naphthalenemethanol
• CAS No.: 10336-29-5
• Molecular Formula: C12H12 O
• Molecular Weight: 172.227
• Hs Code.: 2906299090
• Mol file: 10336-29-5.mol

Synonyms:1-Methyl-8-(hydroxymethyl)naphthalene;8-Methyl-1-naphthalenemethanol

Chemical Property of 8-Methyl-1-naphthalenemethanol

Chemical Property:

• Melting Point: 93-94.5 °C
• Boiling Point: 335.4±11.0 °C(Predicted)
• PKA: 14.38±0.10(Predicted)
• PSA: 20.23000
• Density: 1.120±0.06 g/cm3(Predicted)
• LogP: 2.64050

Purity/Quality:

98%,99%, ^*data from raw suppliers

(8-Methylnaphthalen-1-yl)methanol 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 8-Methyl-1-naphthalenemethanol

There total 8 articles about 8-Methyl-1-naphthalenemethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

1H,3H-benzo[de]isochromene (203-84-9) → 1-hydroxymethyl-8-methylnaphthalene (10336-29-5)

Guidance literature:

1H,3H-benzo[de]isochromene; With 4,4'-di-tert-butylbiphenyl; lithium; In tetrahydrofuran; at -50 ℃; for 6h;

With water; In tetrahydrofuran; at -50 ℃; for 0.25h; Further stages.;

DOI:10.1016/j.tet.2004.03.071

Reference yield: 20.0%

naphthalene-1,8-diyldimethanol (2026-08-6) → 1,8-dimethylnaphthalene (569-41-5) + 1-hydroxymethyl-8-methylnaphthalene (10336-29-5) + (1a,7b-Dihydro-1H-cyclopropa[a]naphthalen-7-yl)-methanol

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; for 144h; Heating;

DOI:10.1039/a700605e

Reference yield: 10.0%

(8-methoxymethyl-naphthalen-1-yl)-methanol (199988-50-6) → 1-hydroxymethyl-8-methylnaphthalene (10336-29-5)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; for 45h; Heating;

DOI:10.1016/S0040-4039(97)10247-7

upstream raw materials:

8-methyl-1-naphthoic acid

naphthalene-1,8-diyldimethanol

(8-methoxymethyl-naphthalen-1-yl)-methanol

1H,3H-benzo[de]isochromene

Downstream raw materials:

1-(methoxymethyl)-8-methylnaphthalene

Refernces

• 1、 Kleinfelter,D.C.,Chen,P.H.. "-". . p. 1741 - 1745. Retrieved 1969.
• 2、 Popovici-Mueller, Janeta V.,Spencer, Thomas A.. "The singular reduction of 1,8-bis-hydroxymethylnaphthalene to a benzonorcaradiene by LiAlH4". . p. 8161 - 8164. Retrieved 1997.
• 3、 -. "METHODS FOR THE TREATMENT OF ALCOHOL ABUSE, ADDICTION AND DEPENDENCY". Page/Page column 18. . Retrieved 2008/12/06.
• 4、 -. "HYDROXY ALKYL SUBSTITUTED 1,3,8-TRIAZASPIRO[4.5]DECAN-4-ONE DERIVATIVES USEFUL FOR THE TREATMENT OF ORL-1 RECEPTOR MEDIATED DISORDERS". Page 178. . Retrieved 2008/06/13.