1,2-bis(3-bromomethyl)phenylethanone

Base Information

• Chemical Name: 1,2-bis(3-bromomethyl)phenylethanone
• CAS No.: 119488-21-0
• Molecular Formula: C₁₆H₁₄Br₂O
• Molecular Weight: 382.095
• Mol file: 119488-21-0.mol

Synonyms:

Chemical Property of 1,2-bis(3-bromomethyl)phenylethanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1,2-bis(3-bromomethyl)phenylethanone

There total 8 articles about 1,2-bis(3-bromomethyl)phenylethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

{3-[2-(3-Hydroxymethyl-benzyl)-[1,3]dioxolan-2-yl]-phenyl}-methanol (119488-25-4) → 1,2-bis(3-bromomethyl)phenylethanone (119488-21-0)

Guidance literature:

With phosphorus tribromide; In benzene; for 12h; Ambient temperature;

DOI:10.3987/COM-88-4485

Reference yield:

trans-1,2-bis-(3-chlorophenyl)ethene (23958-24-9) → 1,2-bis(3-bromomethyl)phenylethanone (119488-21-0)

Guidance literature:

Multi-step reaction with 6 steps

1: 1.) NaBH₄, BF₃*Et₂O; 2.) sodium dichromate dihydrate, 96percent sulfuric acid / 1.) THF, 5 h; 2.) water

2: 86 percent / p-toluenesulfonic acid / benzene / 5 h / Heating

3: 34 percent / N-methyl-2-pyrrolidinone / 24 h / Heating

4: 84 percent / diisobutylaluminum hydride / benzene / 12 h / Ambient temperature

5: 83 percent / NaBH₄ / tetrahydrofuran / 12 h / Ambient temperature

6: 52 percent / PBr₃ / benzene / 12 h / Ambient temperature

With 1-methyl-pyrrolidin-2-one; sodium tetrahydroborate; sodium dichromate; sulfuric acid; boron trifluoride diethyl etherate; phosphorus tribromide; diisobutylaluminium hydride; toluene-4-sulfonic acid; In tetrahydrofuran; benzene;

DOI:10.3987/COM-88-4485

Reference yield:

1,2-bis-(3-chloro-phenyl)-ethanone (119488-20-9) → 1,2-bis(3-bromomethyl)phenylethanone (119488-21-0)

Guidance literature:

Multi-step reaction with 5 steps

1: 86 percent / p-toluenesulfonic acid / benzene / 5 h / Heating

2: 34 percent / N-methyl-2-pyrrolidinone / 24 h / Heating

3: 84 percent / diisobutylaluminum hydride / benzene / 12 h / Ambient temperature

4: 83 percent / NaBH₄ / tetrahydrofuran / 12 h / Ambient temperature

5: 52 percent / PBr₃ / benzene / 12 h / Ambient temperature

With 1-methyl-pyrrolidin-2-one; sodium tetrahydroborate; phosphorus tribromide; diisobutylaluminium hydride; toluene-4-sulfonic acid; In tetrahydrofuran; benzene;

DOI:10.3987/COM-88-4485

upstream raw materials:

{3-[2-(3-Hydroxymethyl-benzyl)-[1,3]dioxolan-2-yl]-phenyl}-methanol

trans-1,2-bis-(3-chlorophenyl)ethene

1,2-bis-(3-chloro-phenyl)-ethanone

C₁₄H₁₁Cl₃