Ethanone, 1,2-bis(3-chlorophenyl)-

Base Information

• Chemical Name: Ethanone, 1,2-bis(3-chlorophenyl)-
• CAS No.: 119488-20-9
• Molecular Formula: C14H10Cl2O
• Molecular Weight: 265.139
• Mol file: 119488-20-9.mol

Synonyms:

Chemical Property of Ethanone, 1,2-bis(3-chlorophenyl)-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Ethanone, 1,2-bis(3-chlorophenyl)-

There total 8 articles about Ethanone, 1,2-bis(3-chlorophenyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

1,2-bis(3-chlorophenyl)-2-oxoethyl benzoate → 1,2-bis-(3-chloro-phenyl)-ethanone (119488-20-9)

Guidance literature:

With palladium(II) trifluoroacetate; hydrogen; [(4S)-4-[5-bis(3,5-di-tert-butyl-4-methoxyphenyl)phosphanyl-1,3-benzodioxol-4-yl]-4,5,6,7-tetrahydro-1,3-benzodioxol-5-yl]-bis(3,5-di-tert-butyl-4-methoxyphenyl)phosphane; In acetone; at 35 ℃; for 24h; under 22502.3 Torr; chemoselective reaction; Glovebox; Autoclave;

DOI:10.1002/anie.201603590

Reference yield:

1-bromo-3-chlorobenzene (108-37-2) + 3'-Chloroacetophenone (99-02-5) → 1,2-bis-(3-chloro-phenyl)-ethanone (119488-20-9)

Guidance literature:

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; bis[2-(diphenylphosphino)phenyl] ether; sodium t-butanolate; In tetrahydrofuran; at 70 ℃; for 3h; Inert atmosphere;

DOI:10.1021/jacs.5b13104

Reference yield:

C14H11Cl3 (146736-42-7) → 1,2-bis-(3-chloro-phenyl)-ethanone (119488-20-9)

Guidance literature:

Multi-step reaction with 2 steps

1: BuOK / tetrahydrofuran; hexane / 5 h / Heating

2: 1.) NaBH₄, BF₃*Et₂O; 2.) sodium dichromate dihydrate, 96percent sulfuric acid / 1.) THF, 5 h; 2.) water

With sodium tetrahydroborate; sodium dichromate; sulfuric acid; boron trifluoride diethyl etherate; potassium n-butoxide; In tetrahydrofuran; hexane;

DOI:10.3987/COM-88-4485

upstream raw materials:

1,2-bis(3-chlorophenyl)ethane-1,2-dione

trans-1,2-bis-(3-chlorophenyl)ethene

C₁₄H₁₁Cl₃

1-Chloro-3-chloromethyl-benzene

Downstream raw materials:

2-(3-Chloro-benzyl)-2-(3-chloro-phenyl)-[1,3]dioxolane

1,2-bis(3-bromomethyl)phenylethanone

C₁₈H₁₆O₄

C₁₈H₁₄N₂O₂