Fmoc-[Cys(N-acetamidomethyl),(2,7)Cys(N-methyl-phenacyloxycarbamidomethyl)(3)]-α-conotoxin SI(1-8)-(4-SC6H4CH2COOH)

Base Information

• Chemical Name: Fmoc-[Cys(N-acetamidomethyl),(2,7)Cys(N-methyl-phenacyloxycarbamidomethyl)(3)]-α-conotoxin SI(1-8)-(4-SC6H4CH2COOH)
• CAS No.: 1314096-88-2
• Molecular Formula: C₆₉H₈₆N₁₂O₁₈S₄
• Molecular Weight: 1499.78
• Mol file: 1314096-88-2.mol

Synonyms:

Chemical Property of Fmoc-[Cys(N-acetamidomethyl),(2,7)Cys(N-methyl-phenacyloxycarbamidomethyl)(3)]-α-conotoxin SI(1-8)-(4-SC6H4CH2COOH)

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Fmoc-[Cys(N-acetamidomethyl),(2,7)Cys(N-methyl-phenacyloxycarbamidomethyl)(3)]-α-conotoxin SI(1-8)-(4-SC6H4CH2COOH)

There total 1 articles about Fmoc-[Cys(N-acetamidomethyl),(2,7)Cys(N-methyl-phenacyloxycarbamidomethyl)(3)]-α-conotoxin SI(1-8)-(4-SC6H4CH2COOH) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 8.0%

Nα-Fmoc-S-(N-methyl-phenacyloxycarbamidomethyl)cysteine (1314096-75-7) + N-(fluoren-9-ylmethoxycarbonyl)glycine (29022-11-5) + N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanine (35661-39-3,136132-75-7) + 4-mercaptophenylacetic acid (39161-84-7) + Fmoc-Pro-OH (71989-31-6) + Fmoc-Ile-OH (71989-23-6,251316-98-0) + L-Asn(Trt) (132388-59-1) + S-[(acetylamino)methyl]-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-cysteine (86060-81-3) → Fmoc-[Cys(N-acetamidomethyl),(2,7)Cys(N-methyl-phenacyloxycarbamidomethyl)(3)]-α-conotoxin SI(1-8)-(4-SC6H4CH2COOH) (1314096-88-2)

Guidance literature:

N-(fluoren-9-ylmethoxycarbonyl)glycine; With piperidine; Fmoc-N-ethyl-S-trityl-L-cysteine; Fmoc-Rink-(4-methylbenzhydrylamine) resin; Nα-(9-fluorenylmethyloxycarbonyl)-Nγ-2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl-L-arginine; In 1-methyl-pyrrolidin-2-one; solid phase reaction;

With acetic anhydride; N-ethyl-N,N-diisopropylamine; In 1-methyl-pyrrolidin-2-one; methanol; dichloromethane; for 0.0833333h; solid phase reaction;

Nα-Fmoc-S-(N-methyl-phenacyloxycarbamidomethyl)cysteine; N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanine; 4-mercaptophenylacetic acid; Fmoc-Pro-OH; Fmoc-Ile-OH; L-Asn(Trt); S-[(acetylamino)methyl]-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-cysteine; Further stages;

DOI:10.1039/c1ob05253e

Reference yield:

[Cys(N-methyl-phenacyloxycarbamidomethyl)(13),Lys(N3)(10)]-α-conotoxin SI(9-13) (1314096-87-1) + Fmoc-[Cys(N-acetamidomethyl),(2,7)Cys(N-methyl-phenacyloxycarbamidomethyl)(3)]-α-conotoxin SI(1-8)-(4-SC6H4CH2COOH) (1314096-88-2) → Fmoc-IC(N-acetamidomethyl)C(N-methyl-phenacyloxycarbamidomethyl)NPAC(N-acetamidomethyl)GPK(N3)YSC(N-methyl-phenacyloxycarbamidomethyl)-NH2 (1314096-89-3)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; 3-hydroxy-3,4-dihydrobenzotriazine-4-one; In dimethyl sulfoxide; at 20 ℃; for 4h;

DOI:10.1039/c1ob05253e

upstream raw materials:

Nα-Fmoc-S-(N-methyl-phenacyloxycarbamidomethyl)cysteine

N-(fluoren-9-ylmethoxycarbonyl)glycine

N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanine

4-mercaptophenylacetic acid

Downstream raw materials:

Fmoc-IC(N-acetamidomethyl)C(N-methyl-phenacyloxycarbamidomethyl)NPAC(N-acetamidomethyl)GPK(N₃)YSC(N-methyl-phenacyloxycarbamidomethyl)-NH₂