trimethyl pyridine-2,4,6-tricarboxylate

Base Information

• Chemical Name: trimethyl pyridine-2,4,6-tricarboxylate
• CAS No.: 25309-39-1
• Molecular Formula: C₁₁H₁₁NO₆
• Molecular Weight: 253.211
• Mol file: 25309-39-1.mol

Synonyms:

Chemical Property of trimethyl pyridine-2,4,6-tricarboxylate

Chemical Property:

• Melting Point: 148-150 °C
• Boiling Point: 385.0±37.0 °C(Predicted)
• PKA: -3.11±0.10(Predicted)
• Density: 1.289±0.06 g/cm3(Predicted)
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

Trimethylpyridine-2,4,6-tricarboxylate 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of trimethyl pyridine-2,4,6-tricarboxylate

There total 9 articles about trimethyl pyridine-2,4,6-tricarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

methanol (67-56-1) + pyridine-2,4,6-tricarboxylic acid (536-20-9) → pyridine-2,4,6-tricarboxylic acid trimethyl ester (25309-39-1)

Guidance literature:

With sulfuric acid; for 6h; Reflux;

DOI:10.1016/j.bioorg.2014.10.007

Reference yield:

2,4,6-trimethyl-pyridine (108-75-8) + methanol (67-56-1) → pyridine-2,4,6-tricarboxylic acid trimethyl ester (25309-39-1)

Guidance literature:

2,4,6-trimethyl-pyridine; With chromium(VI) oxide; sulfuric acid; at 75 ℃; for 24h;

at 4 ℃; for 72h;

methanol; With sulfuric acid; for 12h; Reflux;

DOI:10.1039/d1dt03514b

Reference yield:

2,4,6-trimethyl-pyridine (108-75-8) → pyridine-2,4,6-tricarboxylic acid trimethyl ester (25309-39-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 54.5 percent / KMnO₄ / H₂O / 1.) room temperature, 14 h, 2.) 45-50 deg C, 15 h

2: 68.5 percent / HCl / 240 h / Ambient temperature

With hydrogenchloride; potassium permanganate; In water;

DOI:10.1016/0040-4020(80)85034-4

upstream raw materials:

uvitonic acid

methanol

pyridine-2,4,6-tricarboxylic acid

2,4,6-trimethyl-pyridine

Downstream raw materials:

pyridine-2,4,6-tricarboxylic acid

Refernces

• 1、 Gryko, Dorota,Gryko, Daniel T.,Sierzputowska-Gracz, Hanna,Piatek, Piotr,Jurczak, Janusz. "Factors Influencing the Course of the Macrocyclization of α,ω-Diamines with Esters of α,ω-Dicarboxylic Acids". . p. 156 - 166. Retrieved 2004.
• 2、 Fedorova, Olga A.,Shchukina, Anna A.,Zubenko, Anastasia D.. "Synthetic Approaches to the Bifunctional Chelators for Radio nuclides Based on Pyridine-Containing Azacrown Compounds". . p. 1087 - 1095. Retrieved 2020/04/01.