N-{3-Methoxy-4-[7-((2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-hydroxymethyl-tetrahydro-pyran-2-ylamino)-10H-indolo[3,2-b]quinolin-11-ylamino]-phenyl}-methanesulfonamide

Base Information

Chemical Name:N-{3-Methoxy-4-[7-((2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-hydroxymethyl-tetrahydro-pyran-2-ylamino)-10H-indolo[3,2-b]quinolin-11-ylamino]-phenyl}-methanesulfonamide
CAS No.:136599-34-3
Molecular Formula:C₂₉H₃₁N₅O₈S
Molecular Weight:609.66
Hs Code.:

N-{3-Methoxy-4-[7-((2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-hydroxymethyl-tetrahydro-pyran-2-ylamino)-10H-indolo[3,2-b]quinolin-11-ylamino]-phenyl}-methanesulfonamide

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Chemical Property of N-{3-Methoxy-4-[7-((2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-hydroxymethyl-tetrahydro-pyran-2-ylamino)-10H-indolo[3,2-b]quinolin-11-ylamino]-phenyl}-methanesulfonamide

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Technology Process of N-{3-Methoxy-4-[7-((2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-hydroxymethyl-tetrahydro-pyran-2-ylamino)-10H-indolo[3,2-b]quinolin-11-ylamino]-phenyl}-methanesulfonamide

There total 5 articles about N-{3-Methoxy-4-[7-((2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-hydroxymethyl-tetrahydro-pyran-2-ylamino)-10H-indolo[3,2-b]quinolin-11-ylamino]-phenyl}-methanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 80271-19-8
11-chloro-10H-indolo-[3,2-b]quinoline

: 136599-34-3
N-{3-Methoxy-4-[7-((2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-hydroxymethyl-tetrahydro-pyran-2-ylamino)-10H-indolo[3,2-b]quinolin-11-ylamino]-phenyl}-methanesulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1: 85 percent / HNO₃ / acetic acid / 12 h / Ambient temperature

2: 78 percent / 2-ethoxy-ethanol / 8 h / Heating

3: 78 percent / H₂ / Pd-C (10percent) / acetic acid / Ambient temperature

4: pyridine / dimethylformamide / Ambient temperature

5: NH₃, MeOH-H₂O / Ambient temperature

With pyridine; methanol; ammonia; water; hydrogen; nitric acid; palladium on activated charcoal; In 2-ethoxy-ethanol; acetic acid; N,N-dimethyl-formamide;
DOI:10.1248/cpb.39.1629

Reference yield:

: 131058-48-5
11-chloro-7-nitro-10H-indolo<3,2-b>quinoline

: 136599-34-3
N-{3-Methoxy-4-[7-((2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-hydroxymethyl-tetrahydro-pyran-2-ylamino)-10H-indolo[3,2-b]quinolin-11-ylamino]-phenyl}-methanesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1: 78 percent / 2-ethoxy-ethanol / 8 h / Heating

2: 78 percent / H₂ / Pd-C (10percent) / acetic acid / Ambient temperature

3: pyridine / dimethylformamide / Ambient temperature

4: NH₃, MeOH-H₂O / Ambient temperature

With pyridine; methanol; ammonia; water; hydrogen; palladium on activated charcoal; In 2-ethoxy-ethanol; acetic acid; N,N-dimethyl-formamide;
DOI:10.1248/cpb.39.1629

Reference yield:

: 136539-31-6
N-[3-Methoxy-4-(7-nitro-10H-indolo[3,2-b]quinolin-11-ylamino)-phenyl]-methanesulfonamide; hydrochloride

: 136599-34-3
N-{3-Methoxy-4-[7-((2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-hydroxymethyl-tetrahydro-pyran-2-ylamino)-10H-indolo[3,2-b]quinolin-11-ylamino]-phenyl}-methanesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1: 78 percent / H₂ / Pd-C (10percent) / acetic acid / Ambient temperature

2: pyridine / dimethylformamide / Ambient temperature

3: NH₃, MeOH-H₂O / Ambient temperature

With pyridine; methanol; ammonia; water; hydrogen; palladium on activated charcoal; In acetic acid; N,N-dimethyl-formamide;
DOI:10.1248/cpb.39.1629