3-Methoxypyrazin-2-amine

Base Information

• Chemical Name: 3-Methoxypyrazin-2-amine
• CAS No.: 4774-10-1
• Molecular Formula: C5H7N3O
• Molecular Weight: 125.13
• Hs Code.: 2933990090
• European Community (EC) Number: 893-175-5
• DSSTox Substance ID: DTXSID70500188
• Nikkaji Number: J613.431I
• Wikidata: Q72438934
• Mol file: 4774-10-1.mol

Synonyms:3-methoxypyrazin-2-amine;4774-10-1;2-AMINO-3-METHOXYPYRAZINE;3-METHOXY-2-PYRAZINAMINE;MFCD05722793;Pyrazinamine, 3-methoxy-;3-(methyloxy)-2-pyrazinamine;SCHEMBL1429218;DTXSID70500188;MTMGQKFGZHMTTK-UHFFFAOYSA-N;BCP22353;AKOS005259398;CS-W018865;BL006014;SY021285;TS-01640;A1331;BB 0261705;FT-0645679;EN300-122717;J-200145;Z1198166025

Chemical Property of 3-Methoxypyrazin-2-amine

Chemical Property:

• Vapor Pressure: 0.037mmHg at 25°C
• Melting Point: 84-85ºC
• Refractive Index: 1.567
• Boiling Point: 241.009 °C at 760 mmHg
• PKA: 3.49±0.10(Predicted)
• Flash Point: 99.559 °C
• PSA: 61.03000
• Density: 1.225 g/cm³
• LogP: 0.64860
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• XLogP3: -0.3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 1
• Exact Mass: 125.058911855
• Heavy Atom Count: 9
• Complexity: 88.3

Purity/Quality:

97% ^*data from raw suppliers

2-Amino-3-methoxypyrazine 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=NC=CN=C1N

Technology Process of 3-Methoxypyrazin-2-amine

There total 7 articles about 3-Methoxypyrazin-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

5-bromo-3-methoxypyrazin-2-amine (5900-13-0) → 2-amino-3-methoxypyrazine (4774-10-1)

Guidance literature:

With palladium on activated charcoal; hydrogen; In ethanol; at 20 ℃;

DOI:10.1021/acsmedchemlett.7b00315

Reference yield: 79.0%

N-(2-methoxy-3-pyrazinyl)triphenylphosphazene (180284-25-7) → 2-amino-3-methoxypyrazine (4774-10-1)

Guidance literature:

With water; In tetrahydrofuran; for 72h; Heating;

DOI:10.1055/s-1996-4303

Reference yield: 59.0%

3-chloropyrazin-2-amine (6863-73-6) → 2-amino-3-methoxypyrazine (4774-10-1)

Guidance literature:

With sodium methylate; In methanol;

upstream raw materials:

methanol

3-chloropyrazin-2-amine

N-(2-methoxy-3-pyrazinyl)triphenylphosphazene

2-methoxypyrazine

Downstream raw materials:

2,3-dichloro-N-(3-methoxypyrazin-2-yl)benzenesulfonamide

4-acetylamino-N-(5-bromo-3-methoxy-pyrazin-2-yl)-benzenesulfonamide

5-bromo-3-methoxypyrazin-2-amine

(E)-N-(4-(N-(3-methoxypyrazin-2-yl)sulfamoyl)phenyl)-3-(4-nitrophenyl)acrylamide