(S)-4-(2,3-Dichloro-phenyl)-2,6-dimethyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-ethyl ester 5-[(R)-1-(toluene-4-sulfonylmethyl)-2-trityloxy-ethyl] ester

Base Information

Chemical Name:(S)-4-(2,3-Dichloro-phenyl)-2,6-dimethyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-ethyl ester 5-[(R)-1-(toluene-4-sulfonylmethyl)-2-trityloxy-ethyl] ester
CAS No.:127634-10-0
Molecular Formula:C₄₆H₄₃Cl₂NO₇S
Molecular Weight:824.822
Hs Code.:

(S)-4-(2,3-Dichloro-phenyl)-2,6-dimethyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-ethyl ester 5-[(R)-1-(toluene-4-sulfonylmethyl)-2-trityloxy-ethyl] ester

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Chemical Property of (S)-4-(2,3-Dichloro-phenyl)-2,6-dimethyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-ethyl ester 5-[(R)-1-(toluene-4-sulfonylmethyl)-2-trityloxy-ethyl] ester

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Technology Process of (S)-4-(2,3-Dichloro-phenyl)-2,6-dimethyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-ethyl ester 5-[(R)-1-(toluene-4-sulfonylmethyl)-2-trityloxy-ethyl] ester

There total 7 articles about (S)-4-(2,3-Dichloro-phenyl)-2,6-dimethyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-ethyl ester 5-[(R)-1-(toluene-4-sulfonylmethyl)-2-trityloxy-ethyl] ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 76-83-5
trityl chloride

: 127634-10-0
(S)-4-(2,3-Dichloro-phenyl)-2,6-dimethyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-ethyl ester 5-[(R)-1-(toluene-4-sulfonylmethyl)-2-trityloxy-ethyl] ester

Guidance literature:: Multi-step reaction with 4 steps

1: 95 percent / Et₃N, 4-dimethylaminopyridine / CH₂Cl₂ / 1.5 h / Ambient temperature

2: 98 percent / pyridine / acetone / 1 h / Heating

3: 94 percent / AcOH, piperidine / benzene / 1 h / Heating

4: pyridine / 1 h / Heating

With piperidine; pyridine; dmap; acetic acid; triethylamine; In dichloromethane; acetone; benzene;
DOI:10.1016/S0040-4039(01)93912-7

Reference yield:

: 127634-04-2
(R)-3-p-Tolylsulfanyl-propane-1,2-diol

: 127634-10-0
(S)-4-(2,3-Dichloro-phenyl)-2,6-dimethyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-ethyl ester 5-[(R)-1-(toluene-4-sulfonylmethyl)-2-trityloxy-ethyl] ester

Guidance literature:: Multi-step reaction with 5 steps

1: 83 percent / aq. H₂O₂, o-NO₂C₆H₄SeO₂H / CH₂Cl₂ / 12 h / Ambient temperature

2: 95 percent / Et₃N, 4-dimethylaminopyridine / CH₂Cl₂ / 1.5 h / Ambient temperature

3: 98 percent / pyridine / acetone / 1 h / Heating

4: 94 percent / AcOH, piperidine / benzene / 1 h / Heating

5: pyridine / 1 h / Heating

With piperidine; pyridine; dmap; 2-nitrobenzeneseleninic acid; dihydrogen peroxide; acetic acid; triethylamine; In dichloromethane; acetone; benzene;
DOI:10.1016/S0040-4039(01)93912-7

Reference yield:

: 127634-05-3
(R)-3-(Toluene-4-sulfonyl)-propane-1,2-diol

: 127634-10-0
(S)-4-(2,3-Dichloro-phenyl)-2,6-dimethyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-ethyl ester 5-[(R)-1-(toluene-4-sulfonylmethyl)-2-trityloxy-ethyl] ester

Guidance literature:: Multi-step reaction with 4 steps

1: 95 percent / Et₃N, 4-dimethylaminopyridine / CH₂Cl₂ / 1.5 h / Ambient temperature

2: 98 percent / pyridine / acetone / 1 h / Heating

3: 94 percent / AcOH, piperidine / benzene / 1 h / Heating

4: pyridine / 1 h / Heating

With piperidine; pyridine; dmap; acetic acid; triethylamine; In dichloromethane; acetone; benzene;
DOI:10.1016/S0040-4039(01)93912-7