2-[1-(2,3-Dichloro-phenyl)-meth-(E)-ylidene]-3-oxo-butyric acid (R)-1-(toluene-4-sulfonylmethyl)-2-trityloxy-ethyl ester

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Chemical Name:2-[1-(2,3-Dichloro-phenyl)-meth-(E)-ylidene]-3-oxo-butyric acid (R)-1-(toluene-4-sulfonylmethyl)-2-trityloxy-ethyl ester
CAS No.:127634-08-6
Molecular Formula:C₄₀H₃₄Cl₂O₆S
Molecular Weight:713.678
Hs Code.:

Synonyms:2-[1-(2,3-Dichloro-phenyl)-meth-(E)-ylidene]-3-oxo-butyric acid (R)-1-(toluene-4-sulfonylmethyl)-2-trityloxy-ethyl ester

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Chemical Property of 2-[1-(2,3-Dichloro-phenyl)-meth-(E)-ylidene]-3-oxo-butyric acid (R)-1-(toluene-4-sulfonylmethyl)-2-trityloxy-ethyl ester

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Technology Process of 2-[1-(2,3-Dichloro-phenyl)-meth-(E)-ylidene]-3-oxo-butyric acid (R)-1-(toluene-4-sulfonylmethyl)-2-trityloxy-ethyl ester

There total 6 articles about 2-[1-(2,3-Dichloro-phenyl)-meth-(E)-ylidene]-3-oxo-butyric acid (R)-1-(toluene-4-sulfonylmethyl)-2-trityloxy-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 127634-07-5
3-Oxo-butyric acid (R)-1-(toluene-4-sulfonylmethyl)-2-trityloxy-ethyl ester

: 6334-18-5
2,3-dichlorobenzylaldehyde

: 127634-08-6
2-[1-(2,3-Dichloro-phenyl)-meth-(E)-ylidene]-3-oxo-butyric acid (R)-1-(toluene-4-sulfonylmethyl)-2-trityloxy-ethyl ester

Guidance literature:: With piperidine; acetic acid; In benzene; for 1h; Heating;
DOI:10.1016/S0040-4039(01)93912-7

Reference yield:

: 76-83-5
trityl chloride

: 127634-08-6
2-[1-(2,3-Dichloro-phenyl)-meth-(E)-ylidene]-3-oxo-butyric acid (R)-1-(toluene-4-sulfonylmethyl)-2-trityloxy-ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 95 percent / Et₃N, 4-dimethylaminopyridine / CH₂Cl₂ / 1.5 h / Ambient temperature

2: 98 percent / pyridine / acetone / 1 h / Heating

3: 94 percent / AcOH, piperidine / benzene / 1 h / Heating

With piperidine; pyridine; dmap; acetic acid; triethylamine; In dichloromethane; acetone; benzene;
DOI:10.1016/S0040-4039(01)93912-7

Reference yield:

: 127634-04-2
(R)-3-p-Tolylsulfanyl-propane-1,2-diol

: 127634-08-6
2-[1-(2,3-Dichloro-phenyl)-meth-(E)-ylidene]-3-oxo-butyric acid (R)-1-(toluene-4-sulfonylmethyl)-2-trityloxy-ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 83 percent / aq. H₂O₂, o-NO₂C₆H₄SeO₂H / CH₂Cl₂ / 12 h / Ambient temperature

2: 95 percent / Et₃N, 4-dimethylaminopyridine / CH₂Cl₂ / 1.5 h / Ambient temperature

3: 98 percent / pyridine / acetone / 1 h / Heating

4: 94 percent / AcOH, piperidine / benzene / 1 h / Heating

With piperidine; pyridine; dmap; 2-nitrobenzeneseleninic acid; dihydrogen peroxide; acetic acid; triethylamine; In dichloromethane; acetone; benzene;
DOI:10.1016/S0040-4039(01)93912-7