4,4'-OXYBIS[3-(TRIFLUOROMETHYL)BENZENAMINE]

Base Information

• Chemical Name: 4,4'-OXYBIS[3-(TRIFLUOROMETHYL)BENZENAMINE]
• CAS No.: 344-48-9
• Molecular Formula: C14H10 F6 N2 O
• Molecular Weight: 336.237
• Hs Code.: 2922199090
• Mol file: 344-48-9.mol

Synonyms:m-Toluidine,4,4'-oxybis[a,a,a-trifluoro- (6CI,8CI);2,2'-Bis(trifluoromethyl)-4,4'-diaminodiphenyl ether

Chemical Property of 4,4'-OXYBIS[3-(TRIFLUOROMETHYL)BENZENAMINE]

Chemical Property:

• Boiling Point: 365.7±42.0 °C(Predicted)
• PKA: 4.15±0.10(Predicted)
• PSA: 61.27000
• Density: 1.451±0.06 g/cm3(Predicted)
• LogP: 5.84330

Purity/Quality:

98%, ^*data from raw suppliers

2,2'-Bis(trifluoromethyl)-4,4'-diaminodiphenyl ether ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2,2'-Bis(trifluoromethyl)-4,4'-diaminodiphenyl ether (CAS# 344-48-9) is a useful research chemical compound.
• Description: 2,2'-bis(trifluoromethyl)-4,4'-diaminophenyl ether is an ether derivative, mainly used as an intermediate in organic synthesis.

Technology Process of 4,4'-OXYBIS[3-(TRIFLUOROMETHYL)BENZENAMINE]

There total 4 articles about 4,4'-OXYBIS[3-(TRIFLUOROMETHYL)BENZENAMINE] which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

4,4'-dinitro-2,2'-bistrifluoromethyldiphenyl ether (344-47-8) → diamine 4,4'-oxy-bis[3-(trifluoromethyl)benzenamine] + bis(4-amino-2-trifluoromethylphenyl) ether (344-48-9)

Guidance literature:

With hydrazine hydrate; palladium; In ethanol;

Reference yield:

4,4'-dinitro-2,2'-bistrifluoromethyldiphenyl ether (344-47-8) → bis(4-amino-2-trifluoromethylphenyl) ether (344-48-9)

Guidance literature:

With tin(ll) chloride;

DOI:10.1021/ja01604a022

Reference yield:

4-chloro-3-(trifluoromethyl)nitrobenzene (777-37-7) → bis(4-amino-2-trifluoromethylphenyl) ether (344-48-9)

Guidance literature:

Multi-step reaction with 2 steps

1: DMF; H₂O; KF / 160 °C

2: SnCl₂

With potassium fluoride; water; N,N-dimethyl-formamide; tin(ll) chloride;

DOI:10.1021/ja01604a022

upstream raw materials:

4,4'-dinitro-2,2'-bistrifluoromethyldiphenyl ether

4-chloro-3-(trifluoromethyl)nitrobenzene

Refernces