5-CHLOROIMIDAZO[1,2-A]PYRIDINE-3-CARBALDEHYDE

Base Information

• Chemical Name: 5-CHLOROIMIDAZO[1,2-A]PYRIDINE-3-CARBALDEHYDE
• CAS No.: 198895-50-0
• Molecular Formula: C₈H₅ClN₂O
• Molecular Weight: 180.593
• Hs Code.: 2933998090
• Mol file: 198895-50-0.mol

Synonyms:

Chemical Property of 5-CHLOROIMIDAZO[1,2-A]PYRIDINE-3-CARBALDEHYDE

Chemical Property:

• PKA: 2.56±0.50(Predicted)
• PSA: 34.37000
• Density: 1.42±0.1 g/cm3(Predicted)
• LogP: 1.80020

Purity/Quality:

99% ^*data from raw suppliers

5-Chloroimidazo[1,2-a]pyridine-3-carbaldehyde 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-CHLOROIMIDAZO[1,2-A]PYRIDINE-3-CARBALDEHYDE

There total 4 articles about 5-CHLOROIMIDAZO[1,2-A]PYRIDINE-3-CARBALDEHYDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 37.0%

ethyl acetate-tetrahydrofuran + 6-chloroimidazo[1,2-a]pyridine (63111-79-5) → 5-chloro-3-formylimidazo[1,2-a]pyridine (198895-50-0)

Guidance literature:

With sodium hydroxide; sodium chloride; hexamethylenetetramine; In acetic acid;

Reference yield: 18.0%

hexamethylenetetramine (100-97-0) + 6-chloroimidazo[1,2-a]pyridine (63111-79-5) → 5-chloro-3-formylimidazo[1,2-a]pyridine (198895-50-0)

Guidance literature:

With acetic acid; at 85 ℃; for 5h;

DOI:10.1016/S0040-4020(01)01171-1

Reference yield:

Dichloromethyl methyl ether (4885-02-3) + 6-chloroimidazo[1,2-a]pyridine (63111-79-5) → 5-chloro-3-formylimidazo[1,2-a]pyridine (198895-50-0)

Guidance literature:

With titanium tetrachloride; In dichloromethane; at 20 ℃; for 3h;

DOI:10.1016/S0040-4020(01)01171-1

upstream raw materials:

hexamethylenetetramine

6-chloroimidazo[1,2-a]pyridine

N,N-dimethyl-formamide

Dichloromethyl methyl ether

Refernces

• 1、 -. "Fused imidazopyridine derivatives as antihyperlipidemic agents". . . Retrieved 2008/06/13.