prop-1-en-2-yl (2-fluoro-5-(7-((4-methoxybenzyl)(methyl)amino)-2-methyl[1,6]naphthyridin-3-yl)-4-methylphenyl)carbamate

Base Information

Chemical Name:prop-1-en-2-yl (2-fluoro-5-(7-((4-methoxybenzyl)(methyl)amino)-2-methyl[1,6]naphthyridin-3-yl)-4-methylphenyl)carbamate
CAS No.:1455036-70-0
Molecular Formula:C₂₉H₂₉FN₄O₃
Molecular Weight:500.573
Hs Code.:

Synonyms:

Suppliers and Price of prop-1-en-2-yl (2-fluoro-5-(7-((4-methoxybenzyl)(methyl)amino)-2-methyl[1,6]naphthyridin-3-yl)-4-methylphenyl)carbamate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of prop-1-en-2-yl (2-fluoro-5-(7-((4-methoxybenzyl)(methyl)amino)-2-methyl[1,6]naphthyridin-3-yl)-4-methylphenyl)carbamate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of prop-1-en-2-yl (2-fluoro-5-(7-((4-methoxybenzyl)(methyl)amino)-2-methyl[1,6]naphthyridin-3-yl)-4-methylphenyl)carbamate

There total 12 articles about prop-1-en-2-yl (2-fluoro-5-(7-((4-methoxybenzyl)(methyl)amino)-2-methyl[1,6]naphthyridin-3-yl)-4-methylphenyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 452-63-1
2-Bromo-5-fluorotoluene

: 1455036-70-0
prop-1-en-2-yl (2-fluoro-5-(7-((4-methoxybenzyl)(methyl)amino)-2-methyl[1,6]naphthyridin-3-yl)-4-methylphenyl)carbamate

Guidance literature:: Multi-step reaction with 6 steps

1: nitric acid; sulfuric acid / 0.83 h / -5 - 20 °C

2: hydrogen / ethanol / 2062.71 Torr

3: potassium acetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 100 °C / Inert atmosphere

4: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water / 1 h / 60 °C / Inert atmosphere

5: N-ethyl-N,N-diisopropylamine / 1-methyl-pyrrolidin-2-one / 72 h / 185 °C

6: sodium hydrogencarbonate / ethyl acetate / 4 h / 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sulfuric acid; hydrogen; nitric acid; potassium acetate; sodium hydrogencarbonate; potassium carbonate; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; 1-methyl-pyrrolidin-2-one; ethanol; water; ethyl acetate;
DOI:10.1021/acs.jmedchem.5b00067

Reference yield:

: 1455035-96-7
7-chloro-2-methyl[1,6]naphthyridin-3-yl trifluoromethanesulfonate

: 1455036-70-0
prop-1-en-2-yl (2-fluoro-5-(7-((4-methoxybenzyl)(methyl)amino)-2-methyl[1,6]naphthyridin-3-yl)-4-methylphenyl)carbamate

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water / 1 h / 60 °C / Inert atmosphere

2: N-ethyl-N,N-diisopropylamine / 1-methyl-pyrrolidin-2-one / 72 h / 185 °C

3: sodium hydrogencarbonate / ethyl acetate / 4 h / 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydrogencarbonate; potassium carbonate; N-ethyl-N,N-diisopropylamine; In 1-methyl-pyrrolidin-2-one; water; ethyl acetate;
DOI:10.1021/acs.jmedchem.5b00067

Reference yield:

: 1001756-21-3
4-amino-6-chloropyridine-3-carboxaldehyde

: 1455036-70-0
prop-1-en-2-yl (2-fluoro-5-(7-((4-methoxybenzyl)(methyl)amino)-2-methyl[1,6]naphthyridin-3-yl)-4-methylphenyl)carbamate

Guidance literature:: Multi-step reaction with 5 steps

1: potassium hydroxide / tetrahydrofuran / 1 h / 20 °C

2: pyridine / dichloromethane / 2 h / 0 °C / Inert atmosphere

3: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water / 1 h / 60 °C / Inert atmosphere

4: N-ethyl-N,N-diisopropylamine / 1-methyl-pyrrolidin-2-one / 72 h / 185 °C

5: sodium hydrogencarbonate / ethyl acetate / 4 h / 20 °C

With pyridine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydrogencarbonate; potassium carbonate; N-ethyl-N,N-diisopropylamine; potassium hydroxide; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; dichloromethane; water; ethyl acetate;
DOI:10.1021/acs.jmedchem.5b00067