4-Pyridinamine, 2-chloro-3-methoxy-

Base Information

• Chemical Name: 4-Pyridinamine, 2-chloro-3-methoxy-
• CAS No.: 1227600-23-8
• Molecular Formula: C₆H₇ClN₂O
• Molecular Weight: 158.587
• DSSTox Substance ID: DTXSID201300429
• Mol file: 1227600-23-8.mol

Synonyms:1227600-23-8;4-Pyridinamine, 2-chloro-3-methoxy-;2-chloro-3-methoxypyridin-4-amine;4-amino-2-chloro-3-methoxypyridine;2-chloro-3-methoxy-4-pyridinamine;MFCD11553128;starbld0018707;SCHEMBL8415394;OPZBNOCLLDRHQW-UHFFFAOYSA-N;DTXSID201300429;AKOS006323285;FS-6434;SY275183;CS-0148313;F17572

Chemical Property of 4-Pyridinamine, 2-chloro-3-methoxy-

Chemical Property:

• Boiling Point: 320.7±37.0 °C(Predicted)
• Density: 1.311±0.06 g/cm3(Predicted)
• XLogP3: 1.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 158.0246905
• Heavy Atom Count: 10
• Complexity: 112

Purity/Quality:

99% ^*data from raw suppliers

4-Amino-2-chloro-3-methoxypyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: COC1=C(C=CN=C1Cl)N

Technology Process of 4-Pyridinamine, 2-chloro-3-methoxy-

There total 4 articles about 4-Pyridinamine, 2-chloro-3-methoxy- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

2-chloro-3-methoxy-4-nitropyridine (109613-91-4) → 4-amino-2-chloro-3-methoxypyridine (1227600-23-8)

Guidance literature:

With iron; acetic acid; at 40 ℃; for 1h;

Reference yield:

2-chloro-4-nitropyridin-3-ol (15128-85-5) → 4-amino-2-chloro-3-methoxypyridine (1227600-23-8)

Guidance literature:

Multi-step reaction with 2 steps

1: acetonitrile; methanol; hexane / 13 h / 20 °C

2: acetic acid; iron / 1 h / 40 °C

With iron; acetic acid; In methanol; hexane; acetonitrile;

Reference yield:

2-chloro-3-hydroxypyridine (6636-78-8) → 4-amino-2-chloro-3-methoxypyridine (1227600-23-8)

Guidance literature:

Multi-step reaction with 3 steps

1: sulfuric acid; nitric acid / 2 h / 0 - 20 °C

2: acetonitrile; methanol; hexane / 13 h / 20 °C

3: acetic acid; iron / 1 h / 40 °C

With sulfuric acid; nitric acid; iron; acetic acid; In methanol; hexane; acetonitrile;

upstream raw materials:

2-chloro-4-nitropyridin-3-ol

2-chloro-3-methoxy-4-nitropyridine

2-chloro-3-hydroxypyridine