1-Acetyl-5-(2-aminopropyl)-2,3-dihydro-1H-indole-7-carbonitrile

Base Information

Chemical Name:1-Acetyl-5-(2-aminopropyl)-2,3-dihydro-1H-indole-7-carbonitrile
CAS No.:175837-01-1
Molecular Formula:C14H17N3O
Molecular Weight:243.308
Hs Code.:2933990090
DSSTox Substance ID:DTXSID90602330
Nikkaji Number:J3.164.588C
Mol file:175837-01-1.mol

Synonyms:175837-01-1;1-Acetyl-5-(2-aminopropyl)indoline-7-carbonitrile;1-ACETYL-5-(2-AMINOPROPYL)-2,3-DIHYDRO-1H-INDOLE-7-CARBONITRILE;1H-Indole-7-carbonitrile, 1-acetyl-5-(2-aminopropyl)-2,3-dihydro-;1-ACETYL-5-(2-AMINOPROPYL)-2,3-DIHYDROINDOLE-7-CARBONITRILE;SCHEMBL2354224;DTXSID90602330;MCRFLQWSKTXBBS-UHFFFAOYSA-N;AKOS015909615;AC-23952;DB-065126;AM20090778;F16027;A881553;1-Acetyl-5-(2-aminopropyl)-7-indolinecarbonitrile;Q-102539;1-acetyl-5-(2-aminopropyl)-2,3-dihydroindole-7-carbonitrile

Suppliers and Price of 1-Acetyl-5-(2-aminopropyl)-2,3-dihydro-1H-indole-7-carbonitrile

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
1-Acetyl-5-(2-aminopropyl)indoline-7-carbonitrile
2.5g
$ 950.00

Chemenu
1-Acetyl-5-(2-aminopropyl)indoline-7-carbonitrile 95%
1g
$ 426.00

Biosynth Carbosynth
1-Acetyl-5-(2-aminopropyl)-2,3-dihydro-1H-indole-7-carbonitrile
50 mg
$ 80.00

Biosynth Carbosynth
1-Acetyl-5-(2-aminopropyl)-2,3-dihydro-1H-indole-7-carbonitrile
25 mg
$ 50.00

Biosynth Carbosynth
1-Acetyl-5-(2-aminopropyl)-2,3-dihydro-1H-indole-7-carbonitrile
100 mg
$ 125.00

Biosynth Carbosynth
1-Acetyl-5-(2-aminopropyl)-2,3-dihydro-1H-indole-7-carbonitrile
500 mg
$ 400.00

Biosynth Carbosynth
1-Acetyl-5-(2-aminopropyl)-2,3-dihydro-1H-indole-7-carbonitrile
250 mg
$ 250.00

American Custom Chemicals Corporation
1-ACETYL-5-(2-AMINOPROPYL)INDOLINE-7-CARBONITRILE 95.00%
5MG
$ 499.09

Alichem
1-Acetyl-5-(2-aminopropyl)indoline-7-carbonitrile
250mg
$ 183.82

Alichem
1-Acetyl-5-(2-aminopropyl)indoline-7-carbonitrile
1g
$ 445.12

Total 61 raw suppliers

Chemical Property of 1-Acetyl-5-(2-aminopropyl)-2,3-dihydro-1H-indole-7-carbonitrile

Chemical Property:

Boiling Point:498.585 °C at 760 mmHg
PKA:9.65±0.10(Predicted)
Flash Point:255.335 °C
PSA：70.12000
Density:1.199 g/cm³
LogP:2.12228
Storage Temp.:Hygroscopic, Refrigerator, under inert atmosphere
Solubility.:Chloroform (Slightly), DMSO (Slightly, Heated), Methanol (Slightly)
XLogP3:0.8
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:243.137162174
Heavy Atom Count:18
Complexity:373

Purity/Quality:

99% ^*data from raw suppliers

1-Acetyl-5-(2-aminopropyl)indoline-7-carbonitrile ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(CC1=CC2=C(C(=C1)C#N)N(CC2)C(=O)C)N
Uses 1-Acetyl-5-(2-aminopropyl)indoline-7-carbonitrile is an intermediate in the synthesis of Silodosin (S465000), an α1a-adrenoceptor antagonist. It is used in treatment of benign prostatic hypertophy.

Technology Process of 1-Acetyl-5-(2-aminopropyl)-2,3-dihydro-1H-indole-7-carbonitrile

There total 2 articles about 1-Acetyl-5-(2-aminopropyl)-2,3-dihydro-1H-indole-7-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 160968-97-8
1-acetyl-5-(2-azidopropyl)indoline-7-carbonitrile

: 175837-01-1
1-acetyl-5-(2-aminopropyl)-2,3-dihydro-1H-indole-7-carbonitrile

Guidance literature:: palladium; In ethanol;

Reference yield:

: 160968-96-7
1-acetyl-5-(2-bromopropyl)indoline-7-carbonitrile

: 175837-01-1
1-acetyl-5-(2-aminopropyl)-2,3-dihydro-1H-indole-7-carbonitrile

: 160968-97-8
1-acetyl-5-(2-azidopropyl)indoline-7-carbonitrile

Guidance literature:: In ethoxyethoxyethanol; water;

Reference yield: 93.0%

: 175837-01-1
1-acetyl-5-(2-aminopropyl)-2,3-dihydro-1H-indole-7-carbonitrile

: 160969-03-9
1-(2-methanesulfonyloxyethoxy)-2-(2,2,2-trifluoroethoxy)benzene

: 175837-07-7
1-acetyl-5-(2-((2-(2-(2,2,2-trifluoroethoxy)phenoxy)ethyl)amino)propyl)indoline-7-carbonitrile

Guidance literature:: With potassium carbonate; potassium iodide; In acetonitrile; for 16h; Inert atmosphere; Reflux;
DOI:10.1016/j.tet.2013.01.061