1-acetyl-5-(2-((2-(2-(2,2,2-trifluoroethoxy)phenoxy)ethyl)amino)propyl)indoline-7-carbonitrile

Base Information

Chemical Name:1-acetyl-5-(2-((2-(2-(2,2,2-trifluoroethoxy)phenoxy)ethyl)amino)propyl)indoline-7-carbonitrile
CAS No.:175837-07-7
Molecular Formula:C₂₄H₂₆F₃N₃O₃
Molecular Weight:461.484
Hs Code.:

Synonyms:1-acetyl-5-(2-((2-(2-(2,2,2-trifluoroethoxy)phenoxy)ethyl)amino)propyl)indoline-7-carbonitrile

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Chemical Property of 1-acetyl-5-(2-((2-(2-(2,2,2-trifluoroethoxy)phenoxy)ethyl)amino)propyl)indoline-7-carbonitrile

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Technology Process of 1-acetyl-5-(2-((2-(2-(2,2,2-trifluoroethoxy)phenoxy)ethyl)amino)propyl)indoline-7-carbonitrile

There total 2 articles about 1-acetyl-5-(2-((2-(2-(2,2,2-trifluoroethoxy)phenoxy)ethyl)amino)propyl)indoline-7-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 175837-01-1
1-acetyl-5-(2-aminopropyl)-2,3-dihydro-1H-indole-7-carbonitrile

: 160969-03-9
1-(2-methanesulfonyloxyethoxy)-2-(2,2,2-trifluoroethoxy)benzene

: 175837-07-7
1-acetyl-5-(2-((2-(2-(2,2,2-trifluoroethoxy)phenoxy)ethyl)amino)propyl)indoline-7-carbonitrile

Guidance literature:: With potassium carbonate; potassium iodide; In acetonitrile; for 16h; Inert atmosphere; Reflux;
DOI:10.1016/j.tet.2013.01.061

Reference yield:

: 160969-00-6
1-(2-bromoethoxy)-2-(2,2,2-trifluoroethoxy)benzene

: 175837-01-1
1-acetyl-5-(2-aminopropyl)-2,3-dihydro-1H-indole-7-carbonitrile

: 175837-07-7
1-acetyl-5-(2-((2-(2-(2,2,2-trifluoroethoxy)phenoxy)ethyl)amino)propyl)indoline-7-carbonitrile

Guidance literature:: With sodium hydrogencarbonate; In methanol; diethyl ether; ethanol; dichloromethane;

Reference yield:

: 175837-07-7
1-acetyl-5-(2-((2-(2-(2,2,2-trifluoroethoxy)phenoxy)ethyl)amino)propyl)indoline-7-carbonitrile

: 160970-54-7,2182279-45-2
silodosin

Guidance literature:: Multi-step reaction with 5 steps

1.1: (S)-Mandelic acid / methanol / 0.5 h / Inert atmosphere; Sonication

1.2: 1 h / 20 °C / Inert atmosphere

2.1: triethylamine / dichloromethane / 16.5 h / 0 - 20 °C / Inert atmosphere

3.1: potassium carbonate; water / ethanol / 6 h / Inert atmosphere; Reflux

4.1: sodium hydride / acetonitrile / 0.5 h / 0 °C / Inert atmosphere

4.2: 4 h / Inert atmosphere; Reflux

5.1: sodium hydroxide / methanol / 0.5 h / 20 °C / Inert atmosphere

5.2: 8 h / 20 °C / Inert atmosphere

With (S)-Mandelic acid; water; sodium hydride; potassium carbonate; triethylamine; sodium hydroxide; In methanol; ethanol; dichloromethane; acetonitrile;
DOI:10.1016/j.tet.2013.01.061