(2-(2-Chloroethyl)phenyl)methanol

Base Information

• Chemical Name: (2-(2-Chloroethyl)phenyl)methanol
• CAS No.: 35144-25-3
• Molecular Formula: C9H11 Cl O
• Molecular Weight: 170.639
• Hs Code.: 2909309090
• DSSTox Substance ID: DTXSID20697613
• Wikidata: Q82627551
• Mol file: 35144-25-3.mol

Synonyms:(2-(2-CHLOROETHYL)PHENYL)METHANOL;[2-(2-chloroethyl)phenyl]methanol;1260840-26-3;DTXSID20697613;AKOS006308188;EN300-1698924

Chemical Property of (2-(2-Chloroethyl)phenyl)methanol

Chemical Property:

• PSA: 20.23000
• LogP: 1.96020
• XLogP3: 1.9
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 3
• Exact Mass: 170.0498427
• Heavy Atom Count: 11
• Complexity: 106

Purity/Quality:

98% ^*data from raw suppliers

(2-(2-chloroethyl)phenyl)methanol 95 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C(=C1)CCCl)CO

Technology Process of (2-(2-Chloroethyl)phenyl)methanol

There total 3 articles about (2-(2-Chloroethyl)phenyl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

2-methoxyphenethyl alcohol (7417-18-7) → 1-(2-methoxyphenyl)-ethyl chloride (35144-25-3)

Guidance literature:

With thionyl chloride; In benzene; at 50 ℃; for 2h;

DOI:10.1248/cpb.41.2003

Reference yield:

2-methoxyphenylacetic acid (93-25-4) → 1-(2-methoxyphenyl)-ethyl chloride (35144-25-3)

Guidance literature:

Multistep reaction; (i) LiAlH₄, (ii) SOCl₂, Py;

DOI:10.1021/jo00986a025

Reference yield:

4-methoxyphenyl magnesium bromide (13139-86-1) → 1-(2-methoxyphenyl)-ethyl chloride (35144-25-3)

Guidance literature:

Multi-step reaction with 2 steps

1: anfangs in Aether, zuletzt in Benzol oder Toluol bei Siedetemperatur

2: diethyl ether; SOCl₂ / zuletzt Behandeln bei Siedetemperatur

With thionyl chloride; diethyl ether;

DOI:10.1002/hlca.660280186

upstream raw materials:

2-methoxyphenethyl alcohol

2-methoxyphenylacetic acid

4-methoxyphenyl magnesium bromide

Downstream raw materials:

3-(2-methoxyphenyl)propanenitrile

2-methoxy-benzenepropanoic acid

5-(2-methoxyphenyl)-1-pentene

1-Methoxy-2-(2-methylsulfanyl-ethyl)-benzene