5-Bromo-2-trifluoromethyl-isonicotinic acid

Base Information

• Chemical Name: 5-Bromo-2-trifluoromethyl-isonicotinic acid
• CAS No.: 749875-16-9
• Molecular Formula: C7H3BrF3NO2
• Molecular Weight: 270.006
• Hs Code.: 2933399090
• Mol file: 749875-16-9.mol

Synonyms:4-Pyridinecarboxylicacid, 5-bromo-2-(trifluoromethyl)-;

Chemical Property of 5-Bromo-2-trifluoromethyl-isonicotinic acid

Chemical Property:

• Melting Point: 235-238℃
• Boiling Point: 371.6 °C at 760 mmHg
• PKA: 1.59±0.10(Predicted)
• Flash Point: 178.5 °C
• PSA: 50.19000
• Density: 1.863 g/cm3
• LogP: 2.56110
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Water Solubility.: Slightly soluble in water, soluble in organic solvents.

Purity/Quality:

97% ^*data from raw suppliers

5-Bromo-2-(trifluoromethyl)pyridine-4-carboxylicacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 5-Bromo-2-(trifluoromethyl)pyridine-4-carboxylic acid, is used as an important raw material and intermediate used in organic Synthesis, pharmaceuticals, agrochemicals and dyestuff.

Technology Process of 5-Bromo-2-trifluoromethyl-isonicotinic acid

There total 1 articles about 5-Bromo-2-trifluoromethyl-isonicotinic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

carbon dioxide (124-38-9,18923-20-1) + 5-bromo-2(trifluoromethyl)pyridine (436799-32-5) → 5-bromo-2-(trifluoromethyl)pyridine-4-carboxylic acid (749875-16-9)

Guidance literature:

5-bromo-2(trifluoromethyl)pyridine; With n-butyllithium; diisopropylamine; In tetrahydrofuran; hexanes; at -78 - 0 ℃; for 0.0166667h;

carbon dioxide; In tetrahydrofuran; hexanes; at -78 - -60 ℃; for 1h;

With hydrogenchloride; In water; pH=~ 1;

Reference yield: 100.0%

5-amino-2-fluoro-benzamide (518057-72-2) + 5-bromo-2-(trifluoromethyl)pyridine-4-carboxylic acid (749875-16-9) → 5-bromo-N-(3-carbamoyl-4-fluorophenyl)-2-(trifluoromethyl)pyridine-4-carboxamide

Guidance literature:

With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; triethylamine; In Isopropyl acetate; at 20 ℃; for 1h;

Reference yield: 82.0%

5-bromo-2-(trifluoromethyl)pyridine-4-carboxylic acid (749875-16-9) → 5-bromo-2-trifluoromethylisonicotinamide (1070892-03-3)

Guidance literature:

5-bromo-2-(trifluoromethyl)pyridine-4-carboxylic acid; With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; at 20 ℃; for 2h;

With ammonia; In water; acetonitrile; at 0 ℃; for 0.333333h;

upstream raw materials:

carbon dioxide

5-bromo-2(trifluoromethyl)pyridine

Downstream raw materials:

5-bromo-2-trifluoromethylisonicotinamide

5-bromo-2-trifluoromethylisonicotinonitrile

4-chloro-2-methoxy-5-(6-trifluoromethyl-pyridin-3-yl)-benzoyl chloride

4-chloro-5-(4-cyano-6-trifluoromethyl-pyridin-3-yl)-2-methoxy-benzoic acid

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