Galantamine Hydrobromide Racemic (15 mg)

Base Information

• Chemical Name: Galantamine Hydrobromide Racemic (15 mg)
• CAS No.: 193146-85-9
• Molecular Formula: BrH*C₁₇H₂₁NO₃
• Molecular Weight: 368.271
• Hs Code.: 2939800000
• Mol file: 193146-85-9.mol

Synonyms:

Chemical Property of Galantamine Hydrobromide Racemic (15 mg)

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

racGalanthamineHydrobromide ^*data from reagent suppliers

Safty Information:

• Hazard Codes: T,Xi
• Statements: 25-38-43
• Safety Statements: 26-45

MSDS Files:

Useful:

Technology Process of Galantamine Hydrobromide Racemic (15 mg)

There total 29 articles about Galantamine Hydrobromide Racemic (15 mg) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

(-)-narwedine (510-77-0,26601-10-5) → Galantamine hydrobromide (1953-04-4,98125-73-6,193146-85-9)

Guidance literature:

(-)-narwedine; With L-Selectride; In tetrahydrofuran; for 3.5h; Inert atmosphere; Large scale;

With hydrogen bromide; In tetrahydrofuran; ethanol; at 20 ℃; for 0.5h; Large scale;

DOI:10.1021/op990019q

Reference yield: 94.5%

(-)4a,5,9,10,11,12-hexhydro-3-methoxy-11-methyl-6H-benzofuro[3a,3,2-ef][2]benzazepin-6-one (26601-10-5) → Galantamine hydrobromide (1953-04-4,98125-73-6,193146-85-9)

Guidance literature:

(-)4a,5,9,10,11,12-hexhydro-3-methoxy-11-methyl-6H-benzofuro[3a,3,2-ef][2]benzazepin-6-one; With L-Selectride; In tetrahydrofuran; at 20 ℃; for 1h;

With hydrogen bromide; In ethanol; at 0 ℃; pH=1;

Reference yield: 85.4%

Galantamine (357-70-0) → Galantamine hydrobromide (1953-04-4,98125-73-6,193146-85-9)

Guidance literature:

With hydrogen bromide; In methanol; water; at 25 - 30 ℃; for 3h; Product distribution / selectivity;

upstream raw materials:

(-)-narwedine

(-)4a,5,9,10,11,12-hexhydro-3-methoxy-11-methyl-6H-benzofuro[3a,3,2-ef][2]benzazepin-6-one

galantamine

(-)-galantamine tartarate

Downstream raw materials:

(-)-(4aα,6β)-6-chloro-4a-5,9,10,11,12-hexahydro-3-methoxy-11-methyl-6H-benzofuro[3a,3,2-e,f][2]benzazepin

O-Demethylgalantamine

N-desmethyl galantamine

Refernces

• 1、 -. "METHOD FOR PREPARATION OF PURIFIED GALANTAMINE HYDROBROMIDE". Page/Page column 5-9. . Retrieved 2019/12/15.
• 2、 Trinadhachari, Ganala Naga,Kamat, Anand Gopalkrishna,Prabahar, Koilpillai Joseph,Handa, Vijay Kumar,Srinu, Kukunuri Naga Venkata Satya,Babu, Korupolu Raghu,Sanasi, Paul Douglas. "Commercial scale process of galanthamine hydrobromide involving Luche reduction: Galanthamine process involving regioselective 1,2-reduction of α,β-unsaturated ketone". . p. 406 - 412. Retrieved 2013/06/05.