2-Formyl-benzenesulfonic acid (8R,9S,13S,14S,17S)-17-hydroxy-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-3-yl ester

Base Information

• Chemical Name: 2-Formyl-benzenesulfonic acid (8R,9S,13S,14S,17S)-17-hydroxy-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-3-yl ester
• CAS No.: 112211-82-2
• Molecular Formula: C₂₅H₂₈O₅S
• Molecular Weight: 440.56
• Mol file: 112211-82-2.mol

Synonyms:

Chemical Property of 2-Formyl-benzenesulfonic acid (8R,9S,13S,14S,17S)-17-hydroxy-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-3-yl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-Formyl-benzenesulfonic acid (8R,9S,13S,14S,17S)-17-hydroxy-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-3-yl ester

There total 2 articles about 2-Formyl-benzenesulfonic acid (8R,9S,13S,14S,17S)-17-hydroxy-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-3-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

sodium 2-formylbenzenesulfonate (1008-72-6) → 2-Formyl-benzenesulfonic acid (8R,9S,13S,14S,17S)-17-hydroxy-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-3-yl ester (112211-82-2)

Guidance literature:

Multi-step reaction with 2 steps

1: SOCl₂ / dimethylformamide / 0.05 h / Heating

2: triethyamine / diethyl ether / 5 h

With thionyl chloride; triethylamine; In diethyl ether; N,N-dimethyl-formamide;

DOI:10.1039/c39870000654

Reference yield:

estradiol (50-28-2) + 2-formylbenzene-1-sulfonyl chloride (21639-41-8) → 2-Formyl-benzenesulfonic acid (8R,9S,13S,14S,17S)-17-hydroxy-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-3-yl ester (112211-82-2)

Guidance literature:

With triethylamine; In diethyl ether; for 5h;

DOI:10.1039/c39870000654

Reference yield:

2-Formyl-benzenesulfonic acid (8R,9S,13S,14S,17S)-17-hydroxy-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-3-yl ester (112211-82-2) → Acetic acid (8R,9S,13S,14S)-3-hydroxy-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-17-yl ester (6045-67-6)

Guidance literature:

Multi-step reaction with 2 steps

1: triethyamine / diethyl ether

2: 0.1 M sodium hydroxide / acetone; H₂O / 0.08 h / 25 °C

With sodium hydroxide; triethylamine; In diethyl ether; water; acetone;

DOI:10.1039/c39870000654

upstream raw materials:

estradiol

2-formylbenzene-1-sulfonyl chloride

sodium 2-formylbenzenesulfonate

Downstream raw materials:

Acetic acid (8R,9S,13S,14S)-3-hydroxy-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-17-yl ester