4-(4-nitrophenyl)morpholin-3-one

Base Information

• Chemical Name: 4-(4-nitrophenyl)morpholin-3-one
• CAS No.: 446292-04-2
• Molecular Formula: C10H10N2O4
• Molecular Weight: 222.2
• Hs Code.: 29349990
• Mol file: 446292-04-2.mol

Synonyms:4-(4-NITROPHENYL)MORPHOLIN-3-ONE

Chemical Property of 4-(4-nitrophenyl)morpholin-3-one

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.595
• Boiling Point: 516.802 °C at 760 mmHg
• PKA: -4.12±0.20(Predicted)
• Flash Point: 266.352 °C
• PSA: 75.36000
• Density: 1.379 g/cm³
• LogP: 1.54620
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility.: Chloroform (Slightly), Methanol (Slightly)

Purity/Quality:

NLT 99% ^*data from raw suppliers

4-(4-Nitrophenyl)-3-morpholinone ^*data from reagent suppliers

Safty Information:

• Safety Statements: 24/25

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Reagent used in the preparation of various Morpholine based pharmaceuticals. Rivaroxaban Impurity 52. 4-(4-Nitrophenyl)morpholin-3-one is a reagent used in the preparation of various Morpholine based pharmaceuticals.

Technology Process of 4-(4-nitrophenyl)morpholin-3-one

There total 33 articles about 4-(4-nitrophenyl)morpholin-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.2%

bromoethyloxyacetonitrile (100463-96-5) + 4-nitro-aniline (100-01-6,104810-17-5) → 4-(4-nitrophenyl)-3-morpholinone (446292-04-2)

Guidance literature:

With tetra-(n-butyl)ammonium iodide; potassium carbonate; In N,N-dimethyl-formamide; at 50 - 70 ℃; for 4h;

Reference yield: 92.6%

2-chloroethyl cyanomethyl ether (31250-08-5) + 4-nitro-aniline (100-01-6,104810-17-5) → 4-(4-nitrophenyl)-3-morpholinone (446292-04-2)

Guidance literature:

With tetra-(n-butyl)ammonium iodide; potassium carbonate; In N,N-dimethyl-formamide; at 70 - 90 ℃; for 5h; Temperature;

Reference yield: 92.0%

4-(2-(2-chloroethoxy)acetamido)1-nitrobenzene (811450-82-5) → 4-(4-nitrophenyl)-3-morpholinone (446292-04-2)

Guidance literature:

With potassium carbonate; In acetonitrile; Reflux;

upstream raw materials:

4-(2-(2-chloroethoxy)acetamido)1-nitrobenzene

4-nitro-aniline

1-morpholino-4-nitrobenzene

4-phenylmorpholin-3-one

Downstream raw materials:

4-(4-aminophenyl)morpholin-3-one

Rivaroxaban

4-[4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl]morpholine-3-one

2-((2S)-2-hydroxy-3-{[4-(3-oxomorpholin-4-yl)phenyl]amino}propyl)-1H-isoindole-1,3(2H)-dione

Refernces

• 1、 -. "Synthesis method of 4-(4-aminophenyl)-3-morpholone". . . Retrieved 2021/06/12.
• 2、 Chu, Changhu,Jia, Qiang,Liu, Chaoyang,Qin, Cheng,Sun, Haozhou,Yang, Tiannuo,Yu, Tao. "Facile preparation of 4-(4-nitrophenyl)morpholin-3-one via the acid-catalyzed selective oxidation of 4-(4-nitrophenyl)morpholine by sodium chlorite as the sole oxidant". . p. 2633 - 2638. Retrieved 2020/12/29.