31250-08-5

Usage

Uses

Used in Pharmaceutical Industry:
2-chloroethoxyacetonitrile is used as a synthetic intermediate for the preparation of levocetirizine and its intermediates. Levocetirizine is a second-generation antihistamine used to treat symptoms of allergies such as sneezing, runny nose, and itchy eyes. 2-chloroethoxyacetonitrile's reactivity and functional groups make it an essential component in the synthesis of this medication, contributing to its effectiveness in alleviating allergic symptoms.

InChI:InChI=1/C4H6ClNO/c5-1-3-7-4-2-6/h1,3-4H2

Upstream product

• 1462-33-5 2-chloroethyl chloromethyl ether 
• 71-43-2 benzene 
• 107-06-2 1,2-dichloro-ethane 
• 107-16-4 glycolonitrile 
• 107-04-0 1-Bromo-2-chloroethane 

Downstream Products

• 197968-59-5 2-(1-piperazinyl)ethoxyacetonitrile 
• 446292-04-2 4-(4-nitrophenyl)-3-morpholinone 
• 14869-41-1 (2-chloroethoxy)-acetic acid 
• 109-11-5 morpholine-3-one 
• 17229-14-0 (2-chloro-ethoxy)-acetic acid ethyl ester 
• 83881-47-4 (2-Chloro-ethoxy)-acetic acid methyl ester 

Relevant academic research and scientific papers

A high-purity 4 - (4 - aminophenyl) morpholine -3 - ketone (by machine translation)

The invention relates to a low-cost, high-purity of 4 - (4 - aminophenyl) morpholine - 3 - one (II) of the preparation method. The use of hydroxy acetonitrile and 1, 2 - dihalo substituted ethane in the reaction process for preparing halogenated ethyl oxygen radical second grade nitrile IV, then with the para-nitroaniline III substituted reaction, acid lower ring becomes a 4 - (4 - nitrophenyl) morpholine - 3 - ketone V, 4 - (4 - nitrophenyl) morpholine - 3 - ketone V obtained by hydrogenating and reducing 4 - (4 - aminophenyl) morpholine - 3 - one II. The present invention the used raw materials are cheap and easily obtained, and the cost is low; the process route is simple, safety and environmental protection; the design of each step the reaction selectivity is high, high yield, high purity for the 4 - (4 - aminophenyl) morpholine - 3 - ketone preparation provides a guarantee, to industrial production of high-purity [...]. (by machine translation)

Complexes of macrocyclic compounds

Novel macrocyclic (monocyclic and bicyclic) compounds having nitrogen bridgehead atoms and having in the hydrocarbon bridging chains at least two additional hetero atoms selected from the group consisting of sulfur, oxygen, and nitrogen, when admixed with a compatible cation-donor compound form stable cation-containing macrocyclic complexes which, in turn, can be conveniently dissociated by addition of acid or a quaternizing agent. The novel macrocyclics are valuable for use in the same way and for the same purposes as chelating agents.