(1S)-2-methyl-2,5-diazobicyclo[2.2.1]heptane dihydrobromide

Base Information

• Chemical Name: (1S)-2-methyl-2,5-diazobicyclo[2.2.1]heptane dihydrobromide
• CAS No.: 125224-62-6
• Molecular Formula: 2BrH*C₆H₁₂N₂
• Molecular Weight: 273.999
• Hs Code.: 29335990
• Mol file: 125224-62-6.mol

Synonyms:2,5-Diazabicyclo[2.2.1]heptane,2-methyl-, dihydrobromide, (1S)-; 2,5-Diazabicyclo[2.2.1]heptane, 2-methyl-,dihydrobromide, (1S,4S)- (9CI)

Chemical Property of (1S)-2-methyl-2,5-diazobicyclo[2.2.1]heptane dihydrobromide

Chemical Property:

• Melting Point: 258-259℃
• PSA: 15.27000
• LogP: 0.88710

Purity/Quality:

99.9% ^*data from raw suppliers

(1S,4S)-5-Methyl-2,5-diazabicyclo[2.2.1]heptanedihydrobromide 97.0% ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 43
• Safety Statements: 24-37-24/25

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (1S)-2-methyl-2,5-diazobicyclo[2.2.1]heptane dihydrobromide

There total 25 articles about (1S)-2-methyl-2,5-diazobicyclo[2.2.1]heptane dihydrobromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

(1R,4R)-2-(4-Tolylsulfonyl)-5-methyl-2,5-diazabicyclo<2.2.1>heptane (125224-63-7) → (1S,4S)-2-Methyl-2,5-diazabicyclo<2.2.1>heptane Dihydrobromide (114086-15-6,125224-62-6,125224-64-8)

Guidance literature:

With hydrogen bromide; acetic acid; Ambient temperature;

DOI:10.1021/jo00292a054

Reference yield: 81.0%

(1S,4S)-2-(4-Tolylsulfonyl)-5-methyl-2,5-diazabicyclo<2.2.1>heptane (125109-58-2) → (1S,4S)-2-Methyl-2,5-diazabicyclo<2.2.1>heptane Dihydrobromide (114086-15-6,125224-62-6,125224-64-8)

Guidance literature:

With hydrogen bromide; acetic acid; for 6h; Ambient temperature;

DOI:10.1021/jo00292a054

Reference yield: 81.0%

→ (1S,4S)-2-Methyl-2,5-diazabicyclo<2.2.1>heptane Dihydrobromide (114086-15-6,125224-62-6,125224-64-8)

Guidance literature:

upstream raw materials:

(1S,4S)-2-(4-Tolylsulfonyl)-5-methyl-2,5-diazabicyclo<2.2.1>heptane

(1R,4R)-2-(4-Tolylsulfonyl)-5-methyl-2,5-diazabicyclo<2.2.1>heptane

(2S,4R)-2-Hydroxymethyl-4-hydroxy-1-(4-toluenesulfonyl)-pyrrolidine

(2S,4R)-1-(4-tolylsulfonyl)-4-<(4-tolylsulfonyl)oxy>-2-<<(4-tolylsulfonyl)oxy>methyl>pyrrolidine

Downstream raw materials:

C₄₂H₅₀N₆O₅S

6-[1-cyclobutyl-3-methyl-4-[[(1R,4R)-5-methyl-2,5-diazabicyclo[2.2.1]hept-2-yl]carbonyl]-1H-pyrazol-5-yl]-13-cyclohexyl-3-methoxy-N-[(1-methylethyl)sulfonyl]-7H-indolo[2,1-a][2]benzazepine-10-carboxamide

2-chloro-3,4-bis((4-methoxybenzyl)oxy)-N-(((1S,4S)-2-methyl-2-azabicyclo[2.2.1]heptan-5-yl)methyl)benzamide

2-[(1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1]hept-2-yl]-5-nitrotoluene

Refernces

• 1、 -. "Preparation of 2,5-diazabicyclo[2.2.1]heptanes and intermediates". . . Retrieved 2008/06/13.
• 2、 Jordis,Sauter,Siddiqi,Kuenburg,Bhattacharya. "Synthesis of (1R,4R)- and (1S,4S)-2,5-diazabicyclo[2.2.1]heptanes and their N-substituted derivatives". . p. 925 - 930. Retrieved 2007/10/02.