7-[2-(4-Morpholinyl)ethoxy]-2-(4-nitrophenyl)imidazo[2,1-b]benzothiazole

Base Information

• Chemical Name: 7-[2-(4-Morpholinyl)ethoxy]-2-(4-nitrophenyl)imidazo[2,1-b]benzothiazole
• CAS No.: 950769-60-5
• Molecular Formula: C21H20 N4 O4 S
• Molecular Weight: 424.48
• Mol file: 950769-60-5.mol

Synonyms:7-[2-(Morpholin-4-yl)ethoxy]-2-(4-nitrophenyl)imidazo[2,1-b][1,3]benzothiazole

Chemical Property of 7-[2-(4-Morpholinyl)ethoxy]-2-(4-nitrophenyl)imidazo[2,1-b]benzothiazole

Chemical Property:

• PSA: 113.06000
• Density: 1.479g/cm3
• LogP: 4.29630

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 7-[2-(4-Morpholinyl)ethoxy]-2-(4-nitrophenyl)imidazo[2,1-b]benzothiazole

There total 9 articles about 7-[2-(4-Morpholinyl)ethoxy]-2-(4-nitrophenyl)imidazo[2,1-b]benzothiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

2-(4-nitrophenyl)imidazo[2,1-b][1,3]benzothiazol-7-ol (914224-34-3) + 4-(2-chloroethyl)morpholine hydrochride (3647-69-6) → 4-(2-((2-(4-nitrophenyl)benzo[d]imidazo[2,1-b]thiazol-7-yl)oxy)ethyl)morpholine (950769-60-5)

Guidance literature:

With tetra-(n-butyl)ammonium iodide; potassium carbonate; In N,N-dimethyl-formamide; at 90 - 95 ℃; for 5h;

Reference yield: 95.0%

N-(2-chlorethyl)morpholine (3240-94-6) + 2-(4-nitrophenyl)imidazo[2,1-b][1,3]benzothiazol-7-ol (914224-34-3) → 4-(2-((2-(4-nitrophenyl)benzo[d]imidazo[2,1-b]thiazol-7-yl)oxy)ethyl)morpholine (950769-60-5)

Guidance literature:

With tetra-(n-butyl)ammonium iodide; potassium carbonate; In N,N-dimethyl-formamide; at 90 ℃; for 5h;

Reference yield: 89.3%

6-(2-morpholinoethoxy)benzo[d]thiazol-2-amine + 4-Nitrophenacyl bromide (99-81-0) → 4-(2-((2-(4-nitrophenyl)benzo[d]imidazo[2,1-b]thiazol-7-yl)oxy)ethyl)morpholine (950769-60-5)

Guidance literature:

With sodium hydrogencarbonate; In isopropyl alcohol; for 3h; Reflux;

DOI:10.1016/j.bmcl.2020.127525

upstream raw materials:

N-(2-chlorethyl)morpholine

2-(4-nitrophenyl)imidazo[2,1-b][1,3]benzothiazol-7-ol

4-(2-chloroethyl)morpholine hydrochride

4-Nitrophenacyl bromide

Downstream raw materials:

2-(4-aminophenyl)-7-(2-morpholin-4-ylethoxy)imidazo[2,1-b][1,3]benzothiazole

quizartinib

Quizartinib dihydrochloride

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