mPEG10-CH2COOH

Base Information

• Chemical Name: mPEG10-CH2COOH
• CAS No.: 908258-58-2
• Molecular Formula: C23H46 O13
• Molecular Weight: 530.61
• DSSTox Substance ID: DTXSID80694784
• Wikidata: Q72515816
• Mol file: 908258-58-2.mol

Synonyms:908258-58-2;mPEG10-CH2COOH;m-PEG10-CH2COOH;3,6,9,12,15,18,21,24,27,30,33-UNDECAOXATETRATRIACONTANOIC ACID;2-[2-[2-[2-[2-[2-[2-[2-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]acetic acid;2,5,8,11,14,17,20,23,26,29,32-UNDECAOXATETRATRIACONTAN-34-OIC ACID;m-PEG10-acetic acid;m-PEG11-CH2COOH;m-PEG11-CH2CO2H;SCHEMBL3542228;DTXSID80694784;AKOS040743423;BP-24463;MS-29808;HY-133285;CS-0116193;E83653

Chemical Property of mPEG10-CH2COOH

Chemical Property:

• PSA: 138.83000
• Density: 1.122
• LogP: -0.11660
• XLogP3: -1.8
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 13
• Rotatable Bond Count: 32
• Exact Mass: 530.29384152
• Heavy Atom Count: 36
• Complexity: 429

Purity/Quality:

99% ^*data from raw suppliers

mPEG10-CH2COOH min.97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCC(=O)O
• Description: m-PEG11-CH2COOH is a PEG linker containing a terminal carboxylic acid. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The hydrophilic PEG spacer increases solubility in aqueous media.

Technology Process of mPEG10-CH2COOH

There total 8 articles about mPEG10-CH2COOH which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C27H54O13 → 3,6,9,12,15,18,21,24,27,30,33-undecaoxatetratriacontanoic acid (908258-58-2)

Guidance literature:

With methoxybenzene; trifluoroacetic acid; In dichloromethane; at 20 ℃; for 5h;

Reference yield:

methoxypolyethylene glycols-S-triphenylmethyl-L-cysteine dopamine (114740-40-8) → 3,6,9,12,15,18,21,24,27,30,33-undecaoxatetratriacontanoic acid (908258-58-2)

Guidance literature:

With oxygen; In water; at 80 ℃; for 20h; under 6000.6 Torr; pH=11; Autoclave;

DOI:10.1039/c3cy00252g

Reference yield:

Tetraethylene glycol (112-60-7) → 3,6,9,12,15,18,21,24,27,30,33-undecaoxatetratriacontanoic acid (908258-58-2)

Guidance literature:

Multi-step reaction with 5 steps

1.1: thionyl chloride; triethylamine; dmap / dichloromethane / 0 - 20 °C

2.1: sodium periodate; ruthenium(III) chloride trihydrate / dichloromethane; acetonitrile; water / 0 - 20 °C

3.1: sodium hydride / mineral oil; tetrahydrofuran / 0.5 h / 0 - 20 °C / Inert atmosphere

3.2: 12 h / 20 °C / Inert atmosphere

3.3: 3 h / Inert atmosphere; Reflux

4.1: potassium tert-butylate / tert-butyl alcohol / 2 h / 20 °C

4.2: 12 h / 20 °C

5.1: trifluoroacetic acid; methoxybenzene / dichloromethane / 5 h / 20 °C

With dmap; sodium periodate; thionyl chloride; ruthenium(III) chloride trihydrate; potassium tert-butylate; sodium hydride; methoxybenzene; triethylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; water; acetonitrile; mineral oil; tert-butyl alcohol;

DOI:10.1016/j.bmcl.2018.10.009

upstream raw materials:

methoxypolyethylene glycols-S-triphenylmethyl-L-cysteine dopamine

Tetraethylene glycol

hexaethylene glycol monomethyl ether

O-methyl-decaethylene glycol

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