2,5,8,11,14,17,20-Heptaoxadocosan-22-amine

Base Information

• Chemical Name: 2,5,8,11,14,17,20-Heptaoxadocosan-22-amine
• CAS No.: 170572-38-0
• Molecular Formula: C15H33 N O7
• Molecular Weight: 339.43
• Hs Code.: 2942000090
• DSSTox Substance ID: DTXSID80596092
• Nikkaji Number: J3.205.676H
• Wikidata: Q72481354
• Mol file: 170572-38-0.mol

Synonyms:170572-38-0;m-PEG7-amine;2,5,8,11,14,17,20-HEPTAOXADOCOSAN-22-AMINE;mPEG7-NH2;Methyl-PEG7-amine;2-[2-[2-[2-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethanamine;MFCD13184965;3,6,9,12,15,18,21-heptaoxadocosylamine;mPEG7-amine;SCHEMBL2722835;DTXSID80596092;IQQSLHPGFFGOJW-UHFFFAOYSA-N;AKOS027320733;SB83293;AS-65389;BP-22077;SY251143;HY-120237;CS-0077272;C70281;alpha-Methoxy-omega-amino hepta(ethylene glycol);2,5,8,11,14,17,20 heptaoxadocosan-22-amine;A882011

Chemical Property of 2,5,8,11,14,17,20-Heptaoxadocosan-22-amine

Chemical Property:

• Boiling Point: 409.5±40.0 °C(Predicted)
• PKA: 8.74±0.10(Predicted)
• PSA: 90.63000
• Density: 1.046
• LogP: 0.39140
• Storage Temp.: -20°C
• Solubility.: Soluble in Water, DMSO, DCM, DMF
• XLogP3: -1.7
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 8
• Rotatable Bond Count: 20
• Exact Mass: 339.22570239
• Heavy Atom Count: 23
• Complexity: 210

Purity/Quality:

97% ^*data from raw suppliers

2,5,8,11,14,17,20-Heptaoxadocosan-22-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COCCOCCOCCOCCOCCOCCOCCN
• Description: m-PEG7-amine can react with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The hydrophilic PEG spacer increases solubility in aqueous media.
• Uses: Applications may include: bioconjugation, drug delivery, PEG hydrogel, crosslinker, and surface functionalization

Technology Process of 2,5,8,11,14,17,20-Heptaoxadocosan-22-amine

There total 7 articles about 2,5,8,11,14,17,20-Heptaoxadocosan-22-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

azidoheptaethylene glycol methyl ether (208987-04-6,89485-61-0) → 2,5,8,11,14,17,20-heptaoxadocosan-22-amine (170572-38-0,80506-64-5,869718-87-6)

Guidance literature:

azidoheptaethylene glycol methyl ether; With triphenylphosphine; In tetrahydrofuran; at 20 ℃; for 0.5h;

With water; In tetrahydrofuran; at 20 ℃;

DOI:10.1002/ejoc.201700566

Reference yield: 82.0%

2,5,8,11,14,17,20-heptaoxadocosan-22-yl 4-methylbenzene-1-sulfonate (79622-11-0) → 2,5,8,11,14,17,20-heptaoxadocosan-22-amine (170572-38-0,80506-64-5,869718-87-6)

Guidance literature:

2,5,8,11,14,17,20-heptaoxadocosan-22-yl 4-methylbenzene-1-sulfonate; With sodium azide; In N,N-dimethyl-formamide; at 110 ℃; for 3h;

With triphenylphosphine; In tetrahydrofuran; at 20 ℃; for 18h; Inert atmosphere;

DOI:10.1002/asia.200900679

Reference yield: 56.0%

→ 2,5,8,11,14,17,20-heptaoxadocosan-22-amine (170572-38-0,80506-64-5,869718-87-6)

Guidance literature:

upstream raw materials:

3,6,9,12,15,18,21-heptaoxadocosan-1-ol

2,5,8,11,14,17,20-heptaoxadocosan-22-yl 4-methylbenzene-1-sulfonate

azidoheptaethylene glycol methyl ether

triethylene glucol monomethyl ether

Downstream raw materials:

CH₃(OCH₂CH₂)7-NH-13-cis-retinamide